نتایج جستجو برای: kerbs henseleit buffer

تعداد نتایج: 43286  

Journal: :Circulation research 1990
S C Dennis W A Coetzee E J Cragoe L H Opie

We investigated the hypothesis that an accelerated Na+o-H+i exchange on reperfusion may lead to a displacement of the 3[Na+] [Ca2+]i/o equilibrium in favor of an arrhythmogenic rise in cytosolic [Ca2+]. Supporting evidence was obtained by subjection of isolated rat hearts to 15 minutes of low-flow (5% of control) ischemia and 2 minutes of reperfusion in the presence of a Krebs-Henseleit HEPES b...

1998
Nicholas Molton Michael Brady David Lee Penny Probert

Partial sightedness is a sensory disability which can to some extent be alleviated by artificial aids. Many of the sensory methods used in robotics can be applied in attempts to recapture some of the sensory information a partially sighted person has lost. This paper describes a device which uses sonar and stereo vision sensors for this task. The device is portable, and is worn by the user, giv...

Journal: :Environmental Health Perspectives 1990
R S Labow Y A Barry M Tocchi W J Keon

Di(2-ethylhexyl)phthalate (DEHP), the plasticizer used in the biomedical production of blood storage bags, hemodialysis systems, cardiopulmonary bypass (CPB) circuitry, and intubation tubes, is extracted from the plastic material when it comes into contact with biological fluids and is converted to its principal metabolite, mono(2-ethylhexyl)phthalate (MEHP). We have shown that MEHP causes card...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2003
Yukihiro Yokoyama Hongzhi Xu Nicole Kresge Steve Keller Amir H Sarmadi Rajiv Baveja Mark G Clemens Jian X Zhang

Although the mechanisms of cirrhosis-induced portal hypertension have been studied extensively, the role of thromboxane A(2) (TXA(2)) in the development of portal hypertension has never been explicitly explored. In the present study, we sought to determine the role of TXA(2) in bile duct ligation (BDL)-induced portal hypertension in Sprague-Dawley rats. After 1 wk of BDL or sham operation, the ...

2014
Kylie J. Mansfield Jessica R. Hughes

Inflammation is an important contributor to the aetiology of a number of bladder dysfunctions including interstitial cystitis, painful bladder syndrome, and overactive bladder. The aim of this study was to examine the effects of inflammatory mediators on urothelial ATP release. Human urothelial RT4 cells were exposed to normal buffer or varying concentrations of inflammatory mediators (bradykin...

2005
Adam J. Chicco Carole M. Schneider Reid Hayward

The clinical use of doxorubicin (DOX) is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether voluntary exercise training would confer protection against DOX cardiotoxicity in the isolated perfused rat heart. Female Sprague-Dawley rats were randomly assigned to standard holding cages (SED) or cages with running wheels (VEX) for 8 weeks. Twenty-four hour...

Journal: :Circulation 1999
J Nishizawa A Nakai K Matsuda M Komeda T Ban K Nagata

BACKGROUND The myocardial protective role of heat shock protein (HSP) has been demonstrated. Recently, we reported that ischemia/reperfusion induced a significant activation of heat shock factor (HSF) 1 and an accumulation of mRNA for HSP70 and HSP90. We examined the role of reactive oxygen species (ROSs) in the induction of stress response in the ischemic-reperfused heart. METHODS AND RESULT...

Journal: :Journal of pharmacological and toxicological methods 2011
Mohammed T Al Samri Mariam Al Shamsi Suhail Al-Salam Farida Marzouqi Aysha Al Mansouri Suleiman Al-Hammadi Ghazala Balhaj Shaikha K M Al Dawaar Ruqayya S M S Al Hanjeri Sheela Benedict Manjusha Sudhadevi Walter Conca Harvey S Penefsky Abdul-Kader Souid

INTRODUCTION A novel in vitro system was developed to measure O₂ consumption by murine tissues over several hours. METHODS Tissue specimens (7-35 mg) excised from male Balb/c mice were immediately immersed in ice-cold Krebs-Henseleit buffer, saturated with 95% O₂:5% CO₂. The specimens were incubated at 37 °C in the buffer, continuously gassed with O₂:CO₂ (95:5). [O₂] was determined as a funct...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2005
Adam J Chicco Carole M Schneider Reid Hayward

The clinical use of doxorubicin (DOX) is limited by a dose-dependent cardiotoxicity. The purpose of this study was to determine whether voluntary exercise training would confer protection against DOX cardiotoxicity in the isolated perfused rat heart. Female Sprague-Dawley rats were randomly assigned to standard holding cages or cages with running wheels for 8 wk. Twenty-four hours after the sed...

Journal: :Molecules 2015
Bumjung Kim Kyungjin Lee Khanita Suman Chinannai Inhye Ham Youngmin Bu Hocheol Kim Ho-Young Choi

Ligusticum jeholense has been used as the traditional medicine 'Go-Bon' (Chinese name, Gao-ben) in China and Korea. Considering the increased use of medicinal herbs to treat hypertension, in this study, we aimed to investigate the mechanisms of the vasorelaxation effect caused by L. jeholense. We tested the methanol (MeOH) extract of L. jeholense root and rhizoma for vasorelaxant effects; while...

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