BACKGROUND Hypertrophic scars and keloids result from an abnormal fibrous wound healing process in which tissue repair and regeneration-regulating mechanism control is lost. These abnormal fibrous growths present a major therapeutic dilemma and challenge to the plastic surgeon because they are disfiguring and frequently recur. OBJECTIVE To provide updated clinical and experimental information...

Keloids are benign dermal fibroproliferative neoplasms that occur at sites of cutaneous injury as a result of abnormal wound recovery. They are characterized by excess accumulation of extracellular matrix with thickened and disorganized collagen bundles. Unlike normal scar tissue, keloids do not regress and may extend beyond the confines of the original wound (1). Although the exact etiology of...

OBJECTIVE Keloids and fibroids share a number of biologic and demographic similarities however there are no published reports of the association between them. The objective of this study was to investigate the association between self-reported keloids and ultrasound detected fibroids in a population of young African American women. STUDY DESIGN The Study of Environment, Life-style & Fibroids ...

Objective: To compare the efficacy and tolerability of surgical excision and radiotherapy with those of cryotherapy and intralesional steroid treatment of keloids. Subjects and Methods: Twenty-six patients with a total of 76 keloids were enrolled in this study. Nineteen patients with 44 keloids underwent surgical excision combined with immediate 12-Gy irradiation (group A) while the remaining 9...

BACKGROUND Keloids are abnormal wound responses characterised by excessive deposition of collagen and glycoprotein. They are both aesthetically and symptomatically distressing for most of the patients. There are reports of keloid management with pulsed dye laser (PDL), fractional carbon dioxide (CO2) laser and neodymium-doped yttrium aluminium garnet (Nd:YAG) laser individually and also in comb...

BACKGROUND Keloids are vexatious swelling on the skin or the conjuctiva. The effects and impacts of these lesions have not been assessed in a keloid endemic environment like Nigeria. AIMS The purpose of this study is to assess the psychosocial impact as well as effects of keloids on the subjects in a black African population where lesions are commonly seen. METHODS This is a prospective stu...

BACKGROUND Histologically, keloids contain excess fibroblasts and an overabundance of dermal collagen. Recently, it was reported that chymase induced a profibrotic response via transforming growth factor-β1 (TGF-β1)/Smad activation in keloid fibroblasts (KFs). However, the role of chymase in the local renin-angiotensin system (RAS) in keloids has not been elucidated. This study aims to determin...

Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to t...

Management of earlobe keloids is still controversial. Many different treatment modalities have been employed; however, no single approach has been completely successful. We used combination therapy that included compression therapy, laser excision, and serial steroid injection, which has improved our therapeutic outcomes for earlobe keloids.

Introduction: Keloids result from an abnormal fibrous wound healing process. Effective treatment of keloids still present a significant challenge. Various modalities of therapy may be applied, but none of them has been proved entirely successful. Aim: To evaluate the effectiveness of cryosurgery as a preventive approach after surgical excision of the recurrent auricular keloids. Material and me...