BACKGROUND Gremlin-1, a bone morphogenetic protein (BMP) antagonist, is up-regulated in osteoarthritis (OA). Therefore, we aim to evaluate the correlation between gremlin-1 concentrations and the onset and severity of OA. MATERIAL AND METHODS We performed this cross-sectional study in a population of 212 patients with knee OA and 125 healthy controls. RESULTS Patients with knee OA had higher se...

Fenclozic acid (I.C.I. 54,450: Myalex) has recently been withdrawn from trial because of hepatotoxicity. In a published trial (Chalmers, Kellgren, and Platt, 1969), which suggests that it has some effect as an anti-inflammatory agent in rheumatoid arthritis, up to 400 mg. fenclozic acid were given daily for 10 days to 40 patients and compared with 3 6 g. aspirin daily. Two of these patients sho...

Introduction The loss of glycosaminoglycans (GAGs) and breakdown of collagen are typical characteristics of early osteoarthritis (OA) (1). T1rho mapping has been shown to be sensitive to changes in cartilage proteoglycan loss (2). Previous studies have demonstrated that cartilage T1rho values are elevated in OA patients compared to corresponding healthy subjects (3, 4). Recent work has reported...

Background: This study aimed to investigate the efficacy of Jumpstart Nutrition® dietary supplement (JNDS) for enhancing the skeletal muscle metabolism and function of older adults with knee osteoarthritis (KOA) by evaluating the biomarkers of aberrant levels of serum tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), C-reactive protein (CRP), creatine kinase-muscle (CK-MM), and aldol...

Timothy M Rawson BSc MBBS, Nataliya Brima MSc, Fahad AlMajid MD FRCP, Anton L Pozniak MD FRCP, Azara Janmohamed PhD MRCP, Sundhiya Mandalia PhD, Sheena Basnayake RGN, Lusha Kellgren RGN, Andrew J Copas PhD, Robert F Miller MBBS FRCP Imperial College London, London, UK Research Department of Infection and Population Health, University College London, London, WC1E 6JB, UK St Stephen’s Centre, Che...

The paper describes the contribution made to the understanding of the epidemiology of osteoarthritis by the Arthritis Research Campaign Epidemiology Unit. Kellgren and Lawrence defined the condition radiographically and produced the widely used Atlas of Standard Radiographs of Arthritis. They documented the age- and sex-specific prevalence of osteoarthritis. Based on studies in occupational gro...

Kondal, Sudeep Kulkarni, Viraj Gaikwad, Ashrika Kharat, Amit Pant, AniruddhaThe severity of knee osteoarthritis is graded using the 5-point Kellgren-Lawrence scale where healthy knees are assigned grade 0, and subsequent grades 1–4 represent increasing affliction. Although several methods have been proposed in recent years to develop models that can automatically predict from a given radiograph...