In order to characterize fusion products from yeast protoplasts and their segregants, with important features to the wine making industry, electrophoretic karyotyping and RAPD (Random Amplified Polymorphic DNA) were utilized. Electrophoretic karyotyping was performed by the CHEF (“contour-clamped homogeneous electric field electrophoresis”) method, which allowed the detection of chromosomal ban...

First computer based imaging system for human chromosome analysis was developed in 1976 (Castleman & Melnyk, 1976). This system was developed for automatic scanning of metaphases and chromosome karyotyping. However, the system was not much used because it lacked the required sensitivity and accuracy. Due to recent developments in the field of microelectronics, imaging and computational power, t...