Justicia gendarussa methanolic leaf extracts from five different locations in the Southern region of Peninsular Malaysia and two flavonoids, kaempferol and naringenin, were tested for cytotoxic activity. Kaempferol and naringenin were two flavonoids detected in leaf extracts using gas chromatography-flame ionization detection (GC-FID). The results indicated that highest concentrations of kaempf...

Phytoestrogens exist in edible compounds commonly found in fruits or plants. For long times, phytoestrogens have been used for therapeutic treatments against human diseases, and they can be promising ingredients for future pharmacological industries. Kaempferol is a yellow compound found in grapes, broccoli and yellow fruits, which is one of flavonoid as phytoestrogens. Kaempferol has been sugg...

Matrix metalloproteinase (MMP)-9 degrades type IV collagen in the basement membrane and plays crucial roles in several pathological implications, including tumorigenesis and inflammation. In this study, we analyzed the effect of flavonols on MMP-9 expression in phorbol-12-myristate-13-acetate (PMA)-induced human fibrosarcoma HT-1080 cells. Galangin and kaempferol efficiently decreased MMP-9 sec...

Um novo biflavonol denominado chimarrosídeo (1) e oito flavonóis glicosilados adicionais (2-9) foram isolados das folhas de Chimarrhis turbinata. Suas estruturas foram elucidadas com base nos dados dos experimentos de RMN 1D e 2D, como: 3-O-rutinosilquercetina (2), 3-Orutinosil-kaempferol (3), 3-O-galactopiranosil-(6→1)-ramnopiranosil kaempferol (4), 3-O-βgalactopiranosil-(6→1)-α-ramnopiranosil...

The objective of this study was to examine the biological activity of kaempferol and its rhamnosides. We isolated kaempferol (1), a-rhamnoisorobin (2), afzelin (3), and kaempferitrin (4) as pure compounds by far-infrared (FIR) irradiation of kenaf (Hibiscus cannabinus L.) leaves. The depigmenting and anti-inflammatory activity of the compounds was evaluated by analyzing their structure-activity...

Mucus hypersecretion is an important pathological feature of chronic airway diseases, such as asthma and pulmonary diseases. MUC5AC is a major component of the mucus matrix forming family of mucins in the airways. The initiation of endoplasmic reticulum (ER)-mediated stress responses contributes to the pathogenesis of airway diseases. The present study investigated that ER stress was responsibl...

a flavonol, kaempferol, isolated from the fresh flower petals of c. sativus l. (iridaceae) as the sole component. the structure of the compound was determined by chemical and spectroscopic methods.

background tyrosinase is a copper-containing enzyme, which is widely distributed in microorganisms, animals and plants. it is also a key enzyme in melanin biosynthesis, which plays a crucial role in determining the color of mammalian skin and hair. in addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food ...

Kaempferol has been shown to inhibit vascular formation in endothelial cells. However, the underlying mechanisms are not fully understood. In the present study, we evaluated whether kaempferol exerts antiangiogenic effects by targeting extracellular signal-regulated kinase (ERK)/p38 mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin ...

Aim: A rapid, sensitive and accurate Reversed Phase-High Performance Liquid Chromatography method (RPHPLC) with Photo-diode array Detection (PDA) was developed and validated for the simultaneous determination of Quercetin and Kaempferol in the methanolic extract of Tridax procumbens plant. Method: Whole plant of Tridax procumbens was collected from Dhule District, Shirpur; dried and methanolic ...