Ketoacids (KA) are known to preserve muscle mass among patients with chronic kidney disease (CKD) on a low-protein diet (LPD). The present study was to compare the effects of KA supplemented diet therapy in autophagy and inflammation in CKD rats' skeletal muscle. Rats with 5/6 nephrectomy were randomly divided into three groups and fed with either 11 g/kg/day protein [normal-protein diet (NPD)]...

The PP10 stalagmite from Poleva Cave provides a Late Pleistocene and Holocene isotopic record characteristic for the SW of Romania, a sub-Mediterranean climatic region. The speleothem was dated by eight TIMS and one alpha U-series dates which showed that it was precipitated between ∼75 ka and ∼2 ka with at least two hiatuses. The basal sector of the stalagmite showed a slow-growing regime of ∼0...

Lack of scientific reproducibility is a growing concern and weak experimental practices may contribute to irreproducibility. Here, we describe an optimized and versatile protocol for stereotaxic intrahippocampal administration of Kainic Acid (KA) in mice with a C57Bl6 background. In this protocol, KA administration is combined with in vivo recording of neuronal activity with wired and wireless ...

The present study examined the recent report that transplantation of neonatal striatal tissue into kainic acid (KA) lesioned striatum protected the contralateral striatum from a subsequent KA lesion. We did not find a significant difference in the survival rate of animals that received neonatal striatal transplants into a KA lesioned striatum followed by a subsequent lesion of the contralateral...

We have previously reported that the intracerebroventricular (i.c.v.) administration of kainic acid (KA) results in significant neuronal damage on the hippocampal CA3 region. In this study, we examined possible changes in the blood glucose level after i.c.v. pretreatment with KA. The blood glucose level was elevated at 30 min, began to decrease at 60 min and returned to normal at 120 min after ...

We present the first speleothem-derived central North Africa rainfall record for the last glacial period. The record reveals three main wet periods at 65-61 ka, 52.5-50.5 ka and 37.5-33 ka that lead obliquity maxima and precession minima. We find additional minor wet episodes that are synchronous with Greenland interstadials. Our results demonstrate that sub-tropical hydrology is forced by both...

The solid-state high resolution magic angle spinning nuclear magnetic resonance (HRMAS NMR) technique was applied in this work to characterize and quantify the neurochemical changes in the rat hippocampus (CA1 or CA3) after local administration of kainic acid (KA). Intact tissue samples obtained from the KA treated and control brain samples were analyzed using HRMAS NMR. Metabolite proWles from...

Kanaka Maoli (Indigenous Hawaiians) are blessed with a written literature that documents observations and relationships their environment in the form of chants, stories, genealogies passed down orally for centuries. These literatures connect them to ancestral knowledge highlight species, places, processes importance. Such sayings as Pua ka wiliwili, nanahu manō (When wiliwili blossoms, sharks b...

OBJECTIVES To assess the differences in facial proportions between Korean American (KA) women and North American white (NAW) women and to quantitatively describe aesthetic facial features in the KA women. DESIGN Anthropometric survey and facial aesthetic evaluation. PARTICIPANTS Volunteer sample of KA women (n = 72) who served as models for part 1 of the study and a different sample of KA w...