What will the cities of future be like? This is a question that does not have an unequivocal response. The developed by people who been born yet or are devoted to shaping urban planning policy and markets. Furthermore, these created thanks knowledge exist today. All we can do try draw along general (alternative) guidelines according which those might constructed consequences every alternative. ...

We use conjoint choice questions to investigate people’s preferences for income and reductions in mortality risks delivered by contaminated site remediation policies. Our survey is self-administered using the computer by residents of four cities in Italy with severely contaminated sites. We estimate the Value of a Statistical Life to be about €5-6 million for an immediate risk reduction. If the...

We report on the results of a survey based on conjoint choice experiments that was specifically designed to investigate the effect of context on the Value of a Statistical Life (VSL), an important input into the calculation of the mortality benefits of environmental policies that reduce premature mortality. We define ―context‖ broadly to include i) the cause of death (respiratory illness, cance...

Highly mutable β-lactamases are responsible for the ability of Gram-negative bacteria to resist β-lactam antibiotics. Using site-directed mutagenesis technique, we have produced in vitro a number of recombinant analogs of naturally occurring TEM-type β-lactamases, bearing the secondary substitution Q39K and key mutations related to the extended-spectrum (E104K, R164S) and inhibitor-resistant (M...

The toll/interleukin 1 receptor (TIR) domain-containing adaptor protein (TIRAP) plays an important role in the toll-like receptor (TLR) 2, TLR4, TLR7, and TLR9 signaling pathways. TIRAP anchors to phosphatidylinositol (PI) 4,5-bisphosphate (PIP2) on the plasma membrane and PI (3,4,5)-trisphosphate (PIP3) on the endosomal membrane and assists in recruitment of the myeloid differentiation primary...

Recombinant tissue-type plasminogen activator (tPA, trade name Alteplase), currently the only drug approved by the US Food and Drug Administration and the European Medicines Agency for the treatment of cerebral ischaemic stroke, has been implicated in a number of adverse effects reportedly mediated by interactions with the low-density lipoprotein (LDL) family receptors, including neuronal cell ...

The remediation and redevelopment of brownfields are important for achieving sustainable neighborhoods. Voluntary cleanup programs (VCPs) have been established by most states as the principal tool for brownfield redevelopment. Therefore, it is important to understand what site and neighborhood characteristics make it more likely for brownfield property owners to participate. We provide policy-m...