Increased rubella antibody titres have been reported in patients with juvenile rheumatoid arthritis (JRA) and it has been suggested that rubella virus may be of importance in the aetiology or pathogenesis of the disease. In the present study, rubella and rubeola antibody titres in 85 patients with JRA were compared to age- and sex-matched controls. 41% of the patients did not have rubella antib...

The articles in this series address a fundamental question in pediatric psychology—whether children with chronic illnesses are generally psychologically well adjusted (or at least no more maladjusted than their peers) or whether their illness places them or their families at greater risk for emotional or behavioral difficulties. As the rich literature reviews of these three articles highlight, ...

OBJECTIVE To investigate the relationship between clinical manifestations and sleep abnormalities in patients with juvenile rheumatoid arthritis (JRA). METHODS Twenty-one patients with active polyarticular JRA and 20 healthy controls were enrolled consecutively. Pain and functional impairment were assessed with standardized, validated Brazilian questionnaires. Sleep evaluation was based on pa...

A study was undertaken to examine the relationship between the clinical signs and symptoms of temporomandibular joint (TMJ) disorder and computed tomographic (CT) evidence of destruction of these joints in children afflicted with juvenile rheumatoid arthritis (JRA). A thorough clinical examination including determination of the craniomandibular index (CMI) was performed on each of 37 consecutiv...

OBJECTIVE To assess the reliability of bioelectric impedance analysis (BIA) for predicting total body water (TBW) and extracellular water (ECW) in children affected by juvenile rheumatoid arthritis (JRA). SUBJECTS Thirty-nine children affected by JRA and 23 healthy children of similar age (11.0 +/- 3.6, range 3.0-19.0 y) were recruited for the study. METHODS TBW and ECW were measured by deu...

PURPOSE To (i) investigate the influence of general self-efficacy on quality of life outcomes over time among adolescents with type I diabetes or juvenile rheumatoid arthritis (JRA), (ii) investigate parents' perceptions of general self-efficacy and quality of life of adolescents with diabetes or JRA over time, and (iii) identify possible differences in the evaluations of adolescents and parent...

OBJECTIVE To investigate the potential clinical utility of serial levels of sIL2-R as a marker of disease activity among children with juvenile rheumatoid arthritis (JRA) treated with methotrexate (MTX). METHODS sIL2-R levels, measured by ELISA, were evaluated in 16 JRA patients (10 polyarticular, six systemic-onset) treated with oral, weekly MTX. sIL2-R values were compared with those of 49 ...

Ontology design and maintenance require an expertise in both the domain of application and the ontology language. Realistic ontologies typically model different aspects of an application domain at various levels of granularity; prominent examples are the National Cancer Institute Ontology (NCI), which describes diseases, drugs, proteins, etc., and GALEN, which represents knowledge mainly about ...

Aim To identify the predictive factors for malignancies in children presenting with musculoskeletal pain, and ultimately diagnosed to have JRA or malignancy. Patients and methods: it is a retrospective case-control chart review study examining data from the initial visit of all the patients referred to our Department for musculoskeletal pain during the period January 2001– December 2010 and the...