s/Presentations Martin KR, Narang, P, Xu Y, Kauffman AL, Petit J, Xu HE, Meurice N, and MacKeigan JP, 2011. In silico-based identification of small molecule inhibitors targeted to PTPsigma. TGen/VARI Scientific Retreat, Phoenix, AZ (Poster) Martin KR, Xu Y, Looyenga BD, Davis RJ, Wu CL, Tremblay ML, Xu HE, Mackeigan JP, 2011. Identification of PTPsigma as an autophagic phosphatase. AACR 102nd A...

The joining peptide (JP) portion of pro-opiomelanocortin extracted from mouse pituitary glands has previously been shown to exist in one major and several distinct minor forms (Bennett, H. P. J. (1986) Peptides 7, 614-622). We now confirm the heterogeneous nature of JP extracted from mouse neurointermediate pituitary glands and show that similar forms of JP are also to be found in extracts of p...

BACKGROUND The use of a statistical approach to analyze cumulative adverse event (AE) reports has been encouraged by regulatory authorities. However, data variations affect statistical analyses (eg, signal detection). Further, differences in regulations, social issues, and health care systems can cause variations in AE data. The present study examined similarities and differences between two pu...

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease mainly characterized by B cell hyperactivity. Glucocorticoid (GC) is widely used in SLE for its potent anti-inflammatory and immunosuppressive effects. Despite its important clinical efficacy, high-dose or long-term use of GC can cause severe side effects, such as osteoporosis, osteonecrosis, cataracts, hyperglycemia, coronary...

PBPK MODELING ASSESSMENT OF THE COMPETITIVE METABOLIC INTERACTIONSFOR M-XYLENE, ETHYLBENZENE, AND A LUMPED AROMATIC FRACTION OF JP-8JET FUEL VAPORJerry L. Campbell and Jeffrey W. Fisher Jet Propellant 8 (JP-8), a kerosene-based jet fuel used in the military, is composed of hundreds of hydrocarbons. A PBPK model was developed to assess the metabolic interactions of JP-8 vapor on ...

BACKGROUND A highly organized transverse tubule (T-tubule) network is necessary for efficient Ca(2+)-induced Ca(2+) release and synchronized contraction of ventricular myocytes. Increasing evidence suggests that T-tubule remodeling due to junctophilin-2 (JP-2) downregulation plays a critical role in the progression of heart failure. However, the mechanisms underlying JP-2 dysregulation remain i...

JP-8 jet fuel (similar to commercial/international jet A-1 fuel) is the standard military fuel for all types of vehicles, including the U.S. Air Force aircraft inventory. As such, JP-8 presents the most common chemical exposure in the Air Force, particularly for flight and ground crew personnel during preflight operations and for maintenance personnel performing routine tasks. Personal exposure...

1. Toft G, Hagmar L, Giwercman A, Bonde JP. Epidemiological evidence on reproductive effects of persistent organochlorines in humans. Reprod Toxicol 2004,19:5-26. 2. Toft G, Rignell-Hydbom A, Tyrkiel E, Shvets M, Giwercman A. Quality control workshops in standardization of sperm concentration and motility assessment in multicentre studies. Int J Androl 2005, 28:144-149. 3. Toft G, Axmon A, Giwe...

In this short note, by using mathematical induction and infinite product representations of the functions Jp : R → (−∞, 1] and Ip : R → [1,∞), defined by Jp(x) = 2Γ(p + 1)xJp(x) and Ip(x) = 2Γ(p + 1)xIp(x), an extension of Redheffer’s inequality for the function Jp and a Redheffer-type inequality for the function Ip are established. Here Jp and Ip, denotes the Bessel function and modified Besse...

The Job Provenance (JP) service is designed to automate keeping track of computations on large scale Grids, giving thus users a tool to correctly archive information about their jobs and to re-submit any job in a reconstructed environment. JP provides a permanent minimal record of job (and its environment) related information, to which free-form user annotations can be added. JP also offers the...