نتایج جستجو برای: jip3
تعداد نتایج: 68 فیلتر نتایج به سال:
Kinesin-1 is a microtubule plus-end-directed motor that transports various cargos along the axon. Previous studies have elucidated the physical and genetic interactions between kinesin-1 and cytoplasmic dynein, a microtubule minus-end-directed motor, in neuronal cells. However, the physiological importance of kinesin-1 in the dynein-dependent retrograde transport of cargo molecules remains obsc...
Kinesin-1 transports various cargos along the axon by interacting with the cargos through its light chain subunit. Kinesin light chains (KLC) utilize its tetratricopeptide repeat (TPR) domain to interact with over 10 different cargos. Despite a high sequence identity between their TPR domains (87%), KLC1 and KLC2 isoforms exhibit differential binding properties towards some cargos. We determine...
The conserved protein UNC-16 (JIP3) inhibits the active transport of some cell soma organelles, such as lysosomes, early endosomes, and Golgi, to the synaptic region of axons. However, little is known about UNC-16's organelle transport regulatory function, which is distinct from its Kinesin-1 adaptor function. We used an unc-16 suppressor screen in Caenorhabditis elegans to discover that UNC-16...
A n HIV-1 protein promotes chromosome missegrega-tion by epigenetically modifying centromeric chromatin, Shimura et al. report. Lymphocytes infected with HIV-1 display premature chromatid separation (PCS), in which sister chro-matids come apart too early in mitosis, increasing the possibility of missegregation into the wrong daughter cell. This genomic instability may explain the increased inci...
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