Sulindac is the most extensively investigated clinically relevant chemopreventive nonsteroidal anti-inflammatory drug. Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediate its antitumorigenic effects by inducing apoptosis. Recent evidence suggests that sulindac sulfide engages the mitochondrial pathway involving caspase 9 and Bax to mediate its apoptotic effe...

Propagation of waves in elastic porous media, e.g. polymeric foams, is described by Biot-Allard’s theory [1]. Two classes of characteristic parameters are needed to describe the porous media in this theory. First, non-acoustic parameters: porosity φ, thermal characteristic length Λ′, viscous characteristic length Λ, flow resistivity σ, and tortuosity α∞ which are used in Johnson-Champoux-Allard...

Three new species of Macrelmis Motschulsky, 1859 are described and illustrated based on adult males from Rio de Janeiro, Minas Gerais and São Paulo states (southeastern Brazil). A new species groups definition is proposed for the genus, with a redefinition of the former six (aristeae sp. group, celsa sp. group, isus sp. group, granigera sp. group, milleri sp. group and striata sp. group) and de...

Department of Molecular Pharmacology and Physiology, University of South Florida, College of Medicine, 12901 Bruce B. Downs Blvd., MDC-9, Tampa, FL 33612 U.S.A. (AAB, JC) Department of Chemistry, University of South Florida, College of Arts and Sciences, 4202 E. Fowler Ave., CHE 205A, Tampa, FL 33620 (MCS, JCA) Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, W...

OBJECTIVE--To study the effect of anti-CD4 treatment in patients suffering from refractory systemic onset juvenile chronic arthritis (JCA). METHODS--Two children were treated with the mouse CD4 antibody MAX.16H5. The effects on numbers of circulating CD4 T cells, clinical symptoms and C reactive protein (CRP) level were studied and the appearance of human antimouse immunoglobulin antibodies inv...

OBJECTIVE Leg length discrepancy and excessive knee valgus are potential complications of juvenile chronic arthritis of the knee. The aim of the present study was to evaluate retrospectively the safety and efficacy of temporary stapling of the knee epiphyses in management of valgus deformities of the knee in children with JCA. METHODS Medical data of the patients with temporary epiphyseodesis...

[Purpose] The aims of this study were 1) to examine the convergent validity between Lactate pro 2 and a standard JCA-BM 8000 automatic analyzer using salivary lactate 2) investigate relationship blood levels after vertical squat jump. [Participants Methods] Healthy non-athletes participated in observational study. participants performed jump for 1 min 30 s. Blood measured before exercise Pro 2....

The problem of the proper dimension of the solution of a Multiple Correspondence Analysis (MCA) is discussed, based on both the re-evaluation of the explained inertia sensu Benzécri (Les Cahiers de l’Analyse des Données 4:377–379, 1979) and Greenacre (Multiple correspondence analysis and related methods, Chapman and Hall (Kluwer), Dordrecht, 2006) and a test proposed by Ben Ammou and Saporta (R...