Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However, little is known about the precise mechanisms of IVIg in BP. We investigate the cellular effects of IVIg, toward treatments for BP. Keratinocy...

زمینه و هدف: افزایش عوامل التهابی متعاقب چاقی از دلایل اصلی مرگ‌ومیر است. اگرچه نقش تمرینات ورزشی، محدودیت کالریک مکمل‌های ضداکسایشی در این گزارش شده است، اثر همزمان هر سه مداخله مورد توجه پژوهشگران زیادی ازاین‌رو هدف پژوهش حاضر بررسی هشت هفته تمرین تناوبی شدید، کالری مکمل اسپرولینا بر بافت قلب موش‌های صحرایی تحت رژیم غذای پرچرب بود.مواد روش‌ها: 45 سر موش نر چاق‌شده با غذایی (60 درصد چربی، 20 پ...

زمینه و هدف: کاردیومیوپاتی دیابتی یکی از عوامل خطرزای اصلی برای عوارض قلبی- عروقی دیابت است آنجایی که فعالیت بدنی در بیماران می‌تواند ساختار عملکرد میوکارد را تحت تأثیر قرار دهد، لذا هدف پژوهش حاضر بررسی هشت هفته تمرین تناوبی با شدت بالا (HIIT) بر محتوای پروتئین‌های NF-kB Wnt بافت عضله قلبی موش‌های صحرایی نژاد ویستار مبتلا به نوع دو است.مواد روش‌‌ها: مطالعه 20 سر موش نر سن 8-6 میانگین وزن 9/16±...

PROBLEM Recurrent spontaneous abortion associated with immunologic abnormalities has been termed immunologic abortion. Previously we showed that treatment with low-dose intravenous immunoglobulin (IVIG) appears to be beneficial for older women with immunologic abortion. We now report the results of IVIG treatment in a larger group of women with this disorder. METHOD OF STUDY A total of 99 wom...

BACKGROUND Intravenous immunoglobulin (IVIg) therapy has been shown to have therapeutic benefit in more than 50 inflammatory and immune-related diseases; however, the potential benefit of IVIg in cardiovascular disease is more limited, in part because our understanding of the mechanisms underlying the effects of IVIg in innate immunity is incomplete. METHODS AND RESULTS In this study, a syste...

BACKGROUND Intravenous immunoglobulin (IVIG) is the treatment of choice in Kawasaki disease (KD). IVIG is used to prevent cardiovascular complications related to KD. However, a proportion of KD patients have persistent fever after IVIG treatment and are defined as IVIG resistant. METHODS AND RESULTS To develop a risk scoring system based on genetic markers to predict IVIG responsiveness in KD...

We have recently reported that intravenous Ig (IVIg) inhibits uptake of activated C3 fragments onto antibody-sensitized red blood cells (RBCs). To elucidate the mechanism by which IVIg exerts its effect on the complement system, we examined the possible interference with the C4 step of the classical complement cascade. We examined the capacity of autologous serum containing high concentrations ...

Intravenous immunoglobulin G (IVIg) is widely used against a range of clinical symptoms. For its use in immune modulating therapies such as treatment of immune thrombocytopenic purpura high doses of IVIg are required. It has been suggested that only a fraction of IVIg causes this anti immune modulating effect. Recent studies indicated that this fraction is the Fc-sialylated IgG fraction. The ai...

Kawasaki disease (KD) is an acute febrile vasculitic syndrome of early childhood often complicated by coronary artery lesion that drastically reduces the quality of life. The study aimed to identify a reliable marker for predicting nonresponsiveness to the first course of intravenous immunoglobulin (IVIG) in KD patients. A total of 63 patients with KD were enrolled in the study (IVIG response, ...