Tramadol is a synthetic, centrally acting analgesic. It is the most consumed narcotic drug that is prescribed in the world. Tramadol abuse has dramatically increased in Egypt. Long term use of tramadol can induce endocrinopathy. So, the aim of this study was to analyze the adrenal insufficiency induced by long term use of tramadol in experimental animals and also to assess its withdrawal effect...

In this study, the analgesic potency of constant rate infusion of tramadol hydrochloride and as adjunct to ketoprofen on laparotomy-induced pain was evaluated. Dogs were randomly assigned to 4 groups (n=5). Groups 1, 2 and 3 received 0.5mg/kg/hr, 1.0mg/kg/hr and 2.0mg/kg/hr IV; CRI of tramadol hydrochloride respectively while group 4 which served as control received normal saline. Infusions wer...

The effect of tramadol on the plasma glucose level of streptozotocin (STZ)-induced diabetic rats was investigated. A dose-dependent lowering of plasma glucose was seen in the fasting STZ-induced diabetic rats 30 min after intravenous injection of tramadol. This effect of tramadol was abolished by pretreatment with naloxone or naloxonazine at doses sufficient to block opioid mu-receptors. Howeve...

Pain, whether it is acute or chronic, can induce stress and reduce overall quality of life for domestic felines. Tramadol, a synthetic opioid that exerts analgesic effects by binding to μ-opioid receptors as well as inhibiting neuronal reuptake of norepinephrine and serotonin, can be used alone or in combination with NSAIDs for the treatment of domestic feline pain. Tramadol can be incorporated...

OBJECTIVE This study was to find out the total duration of postoperative analgesia following circumcision in children when Tramadol was used as an adjunct to local anaesthetics in penile block. METHODS Forty children of age 5 - 13 yrs, ASA I & II were enrolled in this study. Patients were premedicated with ketamine and atropine intramuscularly prior to separation from their parents and IV can...

BACKGROUND Inhibition of intestinal peristalsis is a major side effect of opioid analgesics. Although tramadol is an opioid-like analgesic, its effect on gut motility is little known. Therefore, the effect of (+)-tramadol, (-)-tramadol and the major metabolite O-desmethyltramadol on intestinal peristalsis in vitro and their mechanisms of action were examined. Distension-induced peristalsis was ...

BACKGROUND Prevalence of recurrent shoulder dislocation in patients taking tramadol has not been studied yet; so, this study aims to study the recurrent shoulder dislocation following tramadol induced seizure. METHODS In this cross-sectional study, 205 patients with recurrent shoulder dislocation complaints (2 or more) referred to Shafa Orthopedic and Iranmehr hospitals Tehran, Iran, from Oct...

BACKGROUND Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia. CASE REPORT This article reports a patient with tramadol dependency that had psychosis after tramadol withdrawal. CONCLUSION By the increase of tramadol usage for relief of chronic pain, tramadol abuse and ...

We report a young man who had received tramadol for pain control and experienced an uncomfortable sensation in both legs immediately after tramadol withdrawal that worsened at rest and at night, and which could be relieved only by moving the legs. He suffered from insomnia and paced up and down in his house every night. Readministration of tramadol dramatically resolved his symptoms of restless...

Background: Thyroidectomy is painful procedure hence multimodal analgesia required. Superficial cervical plexus block can be used for in thyroid surgeries. USG guided administration safe and latest technique as a part of surgery.Methods: After obtaining consent 60 ASA grade I-II adult patients undergoing elective surgery were included randomly divided into two groups (group B)-0.25% bupivacaine...