نتایج جستجو برای: isotretinoin
تعداد نتایج: 1424 فیلتر نتایج به سال:
We describe a case of skeletal hyperostosis in a 29 year old man presenting with non-inflammatory back pain with a past history of isotretinoin therapy for acne. The development of skeletal hyperostosis, predominantly of the spine, has been reported in association with isotretinoin use and has a radiographic picture similar to diffuse idiopathic skeletal hyperostosis. The prevalence and severit...
BACKGROUND Oral isotretinoin has been used to treat mild to severe hidradenitis suppurativa (HS). OBJECTIVE We reviewed the results of low-dose isotretinoin for 4 to 6 months in the treatment of 68 patients with HS. METHODS This is a retrospective study. Data are presented in terms of response rate, long-term follow-up, and the relation between response rate and severity. RESULTS In 16 pa...
Isotretinoin is a known teratogen affecting the neuronal differentiation in developing brain. Apart from its effects on brain and other craniofacial malformations, it is also known to cause failure of detachment of the lens from the surface ectoderm. Interestingly very little is known about the teratogenic effect of isotretinoin on the development of eye. Hence in the present study we evaluated...
INTRODUCTION There are many adverse effects that have been described for isotretinoin. To the best of our knowledge, this is the first report of a possible association of oral isotretinoin intake with autoimmune thyroiditis and ocular myasthenia gravis (OMG). CASE PRESENTATION A 19-year-old Caucasian male, who had used oral isotretinoin for severe acne disease for the previous six months, was...
purpose: to evaluate tear film status and refractive conditions during and one month after treatment of acne vulgaris with isotretinoin (accutane). methods: this prospective study was performed on 26 eyes of 13 known cases of acne vulgaris. all cases were referred by a dermatologist and were candidates for low dose isotretinoin (0.5 mg/kg). full anterior and posterior segment examination and ob...
Isotretinoin (13-cis-retinoic acid; 13-cisRA) has been shown to significantly improve survival for children with high-risk neuroblastoma. Pharmacokinetics of isotretinoin may be negatively affected by the mode of drug administration and the dosing formula.
In 2001, we reported that mortality may have been higher with isotretinoin (30 mg/d for 3 years) than with placebo in the subgroup of current smokers among the 1,166 patients with definitively resected early-stage non-small cell lung cancer who participated in the randomized, controlled Lung Intergroup Trial. We report the overall and cause (cancer, cardiovascular disease, or other)-specific mo...
BACKGROUND/AIM Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin the...
Question: In patients with acne vulgaris, does treatment with isotretinoin increase the risk of depression? Design: A case-crossover study was performed among subjects who received 1 or more isotretinoin prescriptions from 1984 through 2003. Setting: Data were obtained from the Régie de l’Assurance Maladie du Québec (RAMQ) and Quebec’s hospital discharge (Med-Echo) administrative databases. Pat...
Importance The notion that systemic isotretinoin taken within 6 to 12 months of cutaneous surgery contributes to abnormal scarring or delayed wound healing is widely taught and practiced; however, it is based on 3 small case series from the mid-1980s. Objective To evaluate the body of literature to provide evidence-based recommendations regarding the safety of procedural interventions perform...
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