نتایج جستجو برای: isosorbide mononitrate
تعداد نتایج: 1748 فیلتر نتایج به سال:
BACKGROUND The effects of renin-angiotensin system blockade on nitric oxide (NO), especially in pathological conditions, are far from being established. The influence of kinins and angiotensin type 2 receptor are largely speculative and based mainly on animal studies. This study was aimed to address these aspects in humans. METHODS Eight IgA nephropathy patients with documented clinical and h...
OBJECTIVE To evaluate the safety and efficacy of Isosorbide mononitrate (IMN) as a cervical ripening agent prior to induction of labour in term pregnant women. MATERIALS AND METHODS A randomized placebo-controlled study was conducted on 100 term singleton pregnancies planned for induction of labour. The participants were randomly assigned to two groups. One group received 40 mg IMN and the ot...
In this study, aspirin (AS) and isosorbide 5mononitrate(ISM) sustained bilayer tablets were developed by wet granulation and compression technique, the influence of the contents of PVPP on the dissolution of AS from the tablets was investigated. An orthogonal experiment design was used to optimize ISM sustained release layer. The tablets were tested for their drug content, hardness, thickness, ...
AIMS To assess the effects of the nitric oxide donor 5-isosorbide mononitrate (ISMO) on blood flow in the optic nerve head (ON flow) and choroid (Ch flow). METHODS Laser Doppler flowmetry was used to measure ON flow and Ch flow in 12 normal subjects by aiming the laser beam at the fovea and at the temporal rim, respectively. In a double masked, randomised, crossover design, each subject recei...
Purpose: To investigate the effect of isosorbide mononitrate on diabetic cardiomyopathy (DCM), and potential mechanism action.Methods: The effects + GW4869 cardiac function myocardial fibrosis in DCM rats were determined via hemodynamics, hematoxylin-eosin (H&E) staining Masson staining. Exosomes extracted from serum, differential expressions microribonucleic acids (miRNAs) related to by re...
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