Vibrational spectroscopic imaging has become useful analytical tools for quality control of drug products. In this study, we applied microscopic attenuated total reflection (ATR)-IR and confocal Raman microscopy to elucidate structure creams the formulation design in development semi-solid The model were prepared with prednisolone (PRD) fluconazole (FLC) as active pharmaceutical ingredients oil...

Aim. To develop the content of adhesive composition, being one stages in developing transdermal therapeutic system with anti-inflammatory action. Materials and methods. Using organoleptic research methods, properties affecting process applying to base subsequently quality finished product were studied. Color, consistency homogeneity determined visually, features mass recorded. determine optimal...

The aim of this study was to formulate nanodispersions encapsulate antioxidants extracted from olive mill wastewater (OMW) and phycocyanin Spirulina maxima act as enhancers for the skin’s protection against UV radiation. For purpose, two water-in-oil nanoemulsions were prepared using a low-energy homogenization method. Both systems based on isopropyl myristate continuous phase, while water or m...

This report addresses the safety of the inorganic salts and esters of various fatty alcohols of myristic acid. Most of the esters are used as skin conditioning agents in many types of cosmetics in a range of concentrations. Myristate esters are readily hydrolyzed to the corresponding alcohols and acids, which are then further metabolized. Myristate salts readily dissociate in any likely cosmeti...

Ethanol inhibits the respiratory burst of neutrophils. Therefore, the effects of alcohol-based skin disinfection on oxygen metabolism in neutrophils were tested using 70% ethanol or an ethanol-isopropanol-n-propanol mixture. Neutrophil respiratory burst activity as assessed fluorometrically by oxidation of 2', 7'-dichlorofluorescein diacetate increased at 10 min after disinfection with 70% etha...

The aim of this study was to prepare new w/o microemulsions of naproxen (Np) for topical application and evaluate in vitro permeation of Np. The Pseudo-ternary phase diagrams were constructed for various microemulsions composed of isopropyl myristate (IPM) as oil phase, Span 80, Labrafil M, Labrasol, Cremophor EL as surfactants, ethanol as co-surfactant and water as aqueous phase. Finally, conc...

the purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (ss) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. the influence of various permeation enhancers, such as dimethyl sul...