We study statistical properties of the irregular bursting arising in a class of neuronal models close to the transition from spiking to bursting. Prior to the transition to bursting, the systems in this class develop chaotic attractors, which generate irregular spiking. The chaotic spiking gives rise to irregular bursting. The duration of bursts near the transition can be very long. We describe...

BRAIN SEIZURES, AS IN EPILEPSY, are characterized by massively synchronous firing of neurons. Given the extraordinary complexity of the human brain, it is surprising that epilepsy is not a more common complaint. Episodic brain seizures currently affect 1% of the human population, and causes for the syndrome range from hereditary effects to brain injuries and infectious diseases (Berg 2011). To ...

The GABA-B receptor is densely expressed throughout the brain and has been implicated in many CNS functions and disorders, including addiction, epilepsy, spasticity, schizophrenia, anxiety, cognitive deficits, and depression, as well as various aspects of nervous system development. How one GABA-B receptor is involved in so many aspects of CNS function remains unanswered. Activation of GABA-B r...

The relationship between neuron morphology and function is a perennial issue in neuroscience. Information about synaptic integration, network connectivity, and the specific roles of neuronal subpopulations can be obtained through morphological analysis of key neurons within any given microcircuit. Breathing is essential behavior for humans and all mammals, yet the neural microcircuit that gover...

Mittmann, Thomas and Christian Alzheimer. Muscarinic inhibibuffered oxygenated saline solution containing 19 U/ml papain. Whole cell currents were evoked and recorded using an Axopatch tion of persistent Na current in rat neocortical pyramidal neurons. J. Neurophysiol. 79: 1579–1582, 1998. Muscarinic modulation of 200 amplifier in conjunction with a TL-1 interface and pClamp 6.0 software (all f...

Astman, Nadav, Michael J. Gutnick, and Ilya A. Fleidervish. duction in dendritic action-potential propagation (Colbert Activation of protein kinase C increases neuronal excitability by and Johnston 1998; Tsubokawa and Ross 1997). regulating persistent Na current in mouse neocortical slices. J. NeuIn the present study, we sought to determine the effect rophysiol. 80: 1547–1551, 1998. Effects of ...

Oscillatory activity is an emerging property of thalamocortical system. The patterns and the dominant frequencies of these oscillations depend on the functional state of the brain. Normal oscillatory activities include slow (0.1-15 Hz, present mainly during slow-wave sleep or anesthesia), fast (20-60 Hz) and ultra-fast (100-600 Hz) activities. The fast and ultra-fast activities may be present i...