نتایج جستجو برای: isomerization of chloro
تعداد نتایج: 21165937 فیلتر نتایج به سال:
a green and efficient one-pot, four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3- c ]pyrazo-carbonitrile derivatives catalyzed by borax in water is described. this method provides several advantages such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure. the in vitro cytotoxic activity of the synthesized test compounds wa...
Treatment of 4-heptafluoroisopropyl-2-methoxy-3,5,6-trifluropyridine (4 ) with aqueous ammonia in THF gave 2-amino-3,5-difluoro-4-heptafluoroisopropyl- 6-methoxy pyridine (5) in 7 1% yield. Chlorination of this amine with 'ButOCl at -16°C gave an unstable product, namely 2-dichloroarnino-3,5- difluoro-4-heptafluoroisopropyl-6-methoxy pyridine (6). Iodine-catalysed rearrangement of this dic...
The inability to meet the desired outcomes of anticancer treatment and decrease in success bacterial fungal infections accelerated research these areas. Our group has conducted numerous studies, especially on benzimidazole ring systems’ antiproliferative antimicrobial activities. In this study, activity compounds was tested against A549, A498, HeLa, A375, HepG2 cancer cell lines by MTT assay. A...
abstract ion selective electrodes (ises) are electrochemical sensors that respond selectivity to the activity of ionic species. an ion-selective electrode is an electrochemical device that uses a thin selective membrane or film as the recognition element, and is an electrochemical half-cell equivalent to other half-cells of the zeroth (inert metal in a redox electrolyte). in common methods o...
A one-pot synthesis and X-Ray structural characterization of new highly substituted-allyl carbamates
A one-pot synthesis of new variously substituted γ-chloro-γ, β-allylic carbamates have been carried out starting from β-chloro-α, β-unsaturated aldehydes. The and the corresponding intermediates, alcohols, were fully characterized by (1H 13C) NMR, IR HRMS spectroscopic techniques. crystal structures two allylic carbamates, established single-crystal X-ray diffraction.
Sustainable methods for producing enantiopure drugs have been developed. Chlorohydrins as building blocks several β-blockers synthesized in high enantiomeric purity by chemo-enzymatic methods. The yield of the chlorohydrins increased use catalytic amount base. reason this was found to be reduced formation dimeric by-products compared higher concentration An overall reduction reagents and reacti...
Biological signal transduction by photoactive yellow protein (PYP) in halophilic purple sulfur bacteria is initiated by trans-to-cis isomerization of the p-coumaric acid chromophore (pCa) of PYP. pCa is engaged in two short hydrogen bonds with protein residues E46 and Y42, and it is negatively charged at the phenolate oxygen. We investigated the role in the isomerization process of the E46 shor...
The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro. We show that P38 is necessary for methylation of K36...
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