agent-based modeling Integrating physiology across scales and formalizing hypothesis exploration with including high resolution figures, can be found at: Updated information and services those papers emphasizing adaptive and integrative mechanisms. It is published 12 times a year (monthly) by the American publishes original papers that deal with diverse areas of research in applied physiology, ...

Endotoxin causes gastrointestinal motility disorder. Aim of this study is to clarify inhibitory mechanisms of lipopolysaccharide (LPS) on smooth muscle contraction in rat ileum. Ileal tissues were isolated from control rat or from LPS-induced peritonitis model rat. Treatment with LPS inhibited carbachol (CCh)-mediated contraction in a time-dependent manner. Cyclooxygenase-2 (COX-2) and inducibl...

Hyperglycemia is a condition of increasing blood glucose levels exceeding the normal value in patients with Diabetes mellitus (DM). This study screening to describe that respon hyperglycemic mice administration lactobacillus isolated from sap as an alpha glukosidase inhibitor. The final aim this was measure activity glukosidae inhibitor wistar rats. cultivation de man rogosa sharpe Agar (MRS...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...

Recent research indicate an important role for derailed proteostasis in atrial fibrillation (AF). Major pathways of include disruption microtubule network (MTN). Experimental and clinical studies have documented a significant contribution histone deactylase 6 (HDAC6) mediated MTN. Another major causative factor AF is excessive oxidative stress (OS). However, clear connection MTN with OS not kno...

Three different serine proteinase inhibitors were isolated from rat serum and purified to apparent homogeneity. One of the inhibitors appears to be homologous to a1-proteinase inhibitor isolated from man and other species, but the other two, designated rat proteinase inhibitor I and rat proteinase inhibitor II, seem to have no human counterpart. ac-Proteinase inhibitor (Mr 55000) inhibits tryps...

Fluoxetine, a selective serotonin reuptake inhibitor anti-depressant, causes undesirable side effects, including diarrhea and constipation. This research investigated the direct effects of fluoxetine at 0.001, 0.01, 0.1, 1, 10, 100 µM on duodenal proximal colonic tissue contractions. The investigation aimed to determine related mechanisms using an isolated mouse intestine model. Our study showe...

Complexes of the Bowman-Birk soybean inhibitor with either trypsin or chymotrypsin and with both of these enzymes were isolated by gel atration. Amino acid analyses and molecular weight estimates by gel filtration were consistent with the formation of a 1: 1 molar complex between inhibitor and trypsin or chymotrypsin and a 1: 1: 1 molar complex composed of inhibitor, trypsin, and chymotrypsin. ...

Objective(s): Drug-induced atrial fibrillation (AF) is considered an adverse effect of chemotherapeutic drugs. AF is a crucial risk factor for stroke, heart failure, myocardial infarction, and mortality. Pulmonary veins (PVs) are considered triggers inducing AF, and the sinoatrial node (SAN) may modulate PV activity and participate in AF genesis. AF was associated with...