We previously demonstrated that patients with carcinoembryonic an tigen |CKA|-producing neoplastic tumors, treated with murine monoclonal antibody to CEA, produced antibodies directed against the constant regions [human anti-mouse antibody (HAMA)| and the idiotypes (antiId) of these murine immunoglobulins. In this study, we describe a method for analyzing the presence of such antibodies in the ...

It is becoming increasingly clear that site-specific conjugation offers significant advantages over conventional conjugation chemistries used to make antibody-drug conjugates (ADCs). Site-specific payload placement allows for control over both the drug-to-antibody ratio (DAR) and the conjugation site, both of which play an important role in governing the pharmacokinetics (PK), disposition, and ...

This study was conducted to determine the effects of adding ethanol extract of propolis (EEP) and cumin essential oil (CEO) to diets of broiler chicks on the performance, blood parameters, immune response and carcass traits. A total of 240 day-old Ross-308 broiler chicks were randomly allocated to four treatments with six replicates and 10 birds in each replicate in a completely randomized desi...

patients with malignancy are at higher risk of thrombotic complications due to the hypercoagulability state. our objective in this study was to assess the serum concentrations of homocysteine, anti phospholipid antibodies, and anti cardiolipin in patients with benign and malignant breast tumors and study the effect of chemotherapy on the serum levels of these markers. a case control study was c...

This contribution addresses the questions:  Why International Standards?  What is ISO?  How does ISO develop standards? The focus are the Key principles in standard development: 1. ISO standards respond to a need in the market 2. ISO standards are based on global expert opinion 3. ISO standards are developed through a multi-stakeholder process 4. ISO standards are based on a consensus Finall...

Background: Myocardial infarction (MI) is one of the most important causes of death worldwide. The effect of flunixin meglumine (FM) on MI is unknown. We investigated the protective effect of FM on the serum biochemical profile, malondialdehyde (MDA), and heart histology changes induced by isoproterenol (ISO) in adult male rats. Methods: Rats were randomly divided into four groups of six eac...

In annotating measure expressions such as three days and about 123 km, two recently published ISO standards, ISO-TimeML (ISO, 2012b) and ISOspace (ISO, 2014a), show some inconsistencies, as pointed out in ISO SemAF Principles (ISO, 2014c), a third ISO standards on semantic annotation to be published soon. Other than terminological or semantic inconsistencies introduced in ISO SemAF Principles, ...

Sympathetic nerve activity increases in the heart during cardiac failure. Here, we hypothesized that 1 integrins play a protective role in chronic -adrenergic receptor–stimulated cardiac myocyte apoptosis and heart failure. L-isoproterenol (iso; 400 g/kg per hour) was infused in a group of wild-type (WT) and 1 integrin heterozygous knockout (hKO) mice. Left ventricular structural and functional...