In previous studies, the neuroprotective effect of progestrone in diffuse traumatic brain injury has been shown. This study used mifepristone (RU-486), a potent progesterone receptor antagonist, to evaluatethe hypothesis that the neuroprotective effect of progesterone in traumatic brain injury is mediated by the progesterone receptors. The ovariectomized rats were divided into 6 groups. Brain i...

Background and Aim: Acute injuries of the spine and spinal cord are causing the greatest amount of disability. They produce high cost outcomes for patients and society psychologically and economically. Knowing the epidemiology of these injuries play an important role in planning for prevention and conservative treatment. But now, we have little information about this in our country. The ai...

background injuries and accidents are the first cause of death in the first 5 years of children life in the world; the present study was conducted to investigate the extent and distribution of accidents in the infants under one year in hamadan province, iran. materials and methods:this cross-sectional descriptive-analytic study was carried out using of   data of injuries and accidents related t...

in our country injury and its related sequelae are major public health problems. organizations that are responsible for dealing with these issues must be familiar with the impact of it on national health status and resources to have prioritized their control strategies and also target trauma centers. injury is the 5th cause of death in the whole population and the 1st in the age first decades o...

traumatic head injury is the underlying cause of approximately 5% of all persons with epilepsy and is the major cause of epilepsies starting in young adulthood. penetrating head injury, particularly among soldiers, carries a risk of almost 50% of developing post-traumatic epilepsy (pte), mostly within 6 months to two years after the trauma. early seizures (within one week of the trauma) are dep...

formula one legend michael schumacher hit his head severely while skiing on december 29, 2013. he was operated on for brain decompression and left in a coma fighting for life. in such severe brain injury with cerebral contusion and hemorrhage following head trauma, refractory to medical therapy and with increasing cerebral oedema and intracranial pressure, critically low cerebral perfusion can ...

to date, various approaches have been used in attempt to treat spinal cord injury (sci) but there is no definite treatment for repair of the damaged tissue. it is well known that sci results in a loss of neural tissues and formation of cystic cavities that inhibit regeneration of axons. tissue engineering, in which cells, signals and scaffolds are combined, is one of the most promising areas of...

although spinal cord injury (sci) is one of the most common injuries after a road accident, there is no definite treatment for it. in this regard, nanotechnology has focused to retrieve damaged tissue function by designing of a biomaterial as a mimicking extracellular matrix to reduce inflammation, scar and lactate dehydrogenase, to fill the cyst and improve the graft integration, cell prolifer...

case a 13-year-old boy presented to the ski clinic following a fall and a possible twisting of his right knee. he was not able to bear any weight on his right leg and was experiencing pain in the medial aspect of his right knee. his past medical and surgical histories were unremarkable and he was otherwise in good health. physical examination revealed no ecchymosis or effusion. he had moderate ...