BACKGROUND Ischemic or volatile anesthetic preconditioning is defined as tissue protection from impending ischemic cell damage by repetitive short periods of tissue exposure to ischemia or volatile anesthetics. Objective of this study was to elucidate, if ischemic preconditioning and pharmacological preconditioning with sevoflurane have effects on muscle tissue oxygen saturation in patients und...

The concept of ischemic preconditioning refers to myocardial protection from ischemia-reperfusion insult by preceding brief ischemic episodes (1). An extensive effort has been made to understand the time frames and underlying mechanisms of ischemic preconditioning because of the potential applicability of this phenomenon in the clinical setting, especially because “preconditioning-mimetic” agen...

PURPOSE The study aimed to assess whether exposure to ischemic preconditioning (IPC) in a trained population would affect land-based maximal sprinting performance over 30 m. METHODS Twenty-five well-trained participants regularly involved in invasion-type team-sport events were recruited to take part in a randomized crossover study design. Participants underwent both an IPC and a placebo trea...

Three-dimensional electrogram was used for analysis of ischemia manifestation in isolated hearts. Three parameters based on spherical coordination system were used in this study - amplitude of electrical heart vector, its azimuth and elevation. The parameters were presented as a trend. This approach reflected ischemic changes in a manner which can be easily observed and evaluated. Ischemia was ...

There is accumulating evidence, that ischemic preconditioning - a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We have established bilateral common carotid artery occlusion as a preconditioning stimulus to induce early ischemic tolerance to transient focal cerebral ischemia in C57Bl6/J mice. In this video, we will demons...

BACKGROUND It has been demonstrated that brief episodes of sublethal ischemia-reperfusion, so-called ischemic preconditioning, provide powerful tissue protection in different tissues such as heart, brain, skeletal muscle, lung, liver, intestine, kidney, retina, and endothelial cells. Although a recent study has claimed that there are no protective effects of ischemic preconditioning in rat test...

In the brain, brief episodes of ischemia induce tolerance against a subsequent severe episode of ischemia. This phenomenon of endogenous neuroprotection is known as preconditioning-induced ischemic tolerance. The purpose of this review is to summarize the current state of knowledge about mechanisms and potential applications of cerebral preconditioning and ischemic tolerance. Articles related t...

THE IDEA THAT EXPOSURE TO sublethal ischemia could confer protection against a subsequent ischemic insult goes back at least as far as 1989, when Miyazaki and Zipes (13) reported that a sequence of four 5-min coronary occlusions reduced the autonomic denervation produced by a subsequent coronary occlusion in dog hearts. This idea rapidly gained popularity, and, in 1994, Kato et al. (10) reporte...

Our previous studies have demonstrated that the JNK signaling pathway plays an important role in ischemic brain injury and is mediated via glutamate receptor 6. Others studies have shown that N-methyl-d-aspartate (NMDA) receptor is involved in the neuroprotection of ischemic preconditioning. Here we examined whether ischemic preconditioning down-regulates activation of the mixed lineage kinase-...