Optic neuropathy is a frequent cause of vision loss encountered by ophthalmologist. The diagnosis is made on clinical grounds. The history often points to the possible etiology of the optic neuropathy. A rapid onset is typical of demyelinating, inflammatory, ischemic and traumatic causes. A gradual course points to compressive, toxic/nutritional and hereditary causes. The classic clinical signs...

toxic optic neuropathy (ton) is a group of medical disorders which can be defined by visual impairment due to optic nerve damage by a toxin. the exposure to a toxic substance can occur at the workplace, with ingestion of materials/ foods containing a toxin, or the use of systemic medications. ton is a disease entity which is not only under-diagnosed, but also often diagnosed at a stage when rec...

The optic nerve and chiasm, obtained at autopsy, from 53 cases with clinical histories of cerebrovascular disturbances were histopathologically investigated, and ischemic changes in the posterior portion of the optic nerve were revealed in 12 cases. The progress of posterior ischemic optic neuropathy might be divided into necrotic, liquefactive and scar stages. The lesions were located in the t...

1. Postoperative Visual Loss Study Group: Risk factors associated with ischemic optic neuropathy after spinal fusion surgery. ANESTHESIOLOGY 2012; 116:15–24 2. Shen Y, Drum M, Roth S: The prevalence of perioperative visual loss in the United States: A 10-year study from 1996 to 2005 of spinal, orthopedic, cardiac, and general surgery. Anesth Analg 2009; 109:1534 – 45 3. Mathews MK: Nonarteritic...

The neurological manifestations of chronic hepatitis C is most often a peripheral sensory neuropathy characterised by numbness, burning and sensation of "pins and needles". Peripheral motor neuropathy, mononeuropathy, mononeuropathy multiplex and transverse myelitis also occur. Ischemic stroke and transient cerebral ischemia have also been reported. Anterior ischemic optic neuropathy is seen, o...

The causes of nonglaucomatous optic disk atrophy and excavation are enumerated in people 65 years or older: congenital anomalies, myopia, ischemic disorders, transsynaptic degeneration, traumatic, compressive, hereditary, toxic and infectious optic neuropathy.

Large spectrums of ophthalmic manifestations from the anterior to the posterior segment have been so far reported in patients with inflammatory bowel disease. Anterior ischemic optic neuropathy is caused by acute ischemic infarction of the optic nerve head and is distinguished in two different types, non-arteritic anterior ischemic optic neuroparhy (NAION) which is the most frequent type and ar...

Giant cell arteritis is a systemic granulomatous vasculitis affecting medium to large arteries. An arteritic anterior ischemic optic neuropathy is the most common cause of permanent visual loss. Giant cell arteritis is very rare among Asians. We report six patients with biopsy-proven arteritic anterior ischemic optic neuropathy. Demographic data, clinical manifestations, laboratory findings, tr...