INTRODUCTION AND OBJECTIVES Although it is known that the presence of myocardial viability predicts an increase in ejection fraction after revascularization in patients with ischemic cardiomyopathy, little is known about other predictive factors. The aim of this study was to identify variables that can predict an increase in ejection fraction after coronary revascularization surgery in patients...

Existing molecular knowledge base of cardiovascular diseases is rudimentary because of lack of specific attribution to cell type and function. The aim of this study was to investigate cell-specific molecular remodeling in human atrial and ventricular myocytes associated with ischemic cardiomyopathy. Our strategy combines two technological innovations, laser-capture microdissection of identified...

Recent trends indicate that patients with nonischemic dilated cardiomyopathy represent the largest subpopulation of heart failure patients with a significant need for alternative treatment modalities. Similar to patients with ischemic cardiomyopathy, patients with nonischemic dilated cardiomyopathy have been found to have myocardial regions with flow abnormalities, which may represent targets f...

The Syrian cardiomyopathic hamster (SCH) is an established animal model for genetic cardiomyopathy. The disease in the hamster develops through similar stages to those observed in humans with this condition. The pathophysiological basis for this condition in the hamster resides in an inherited mutation in the gene encoding for delta-sarcoglycan, a component of the dystrophin complex. Two basic ...