نتایج جستجو برای: isatin n sulfonic issa
تعداد نتایج: 980367 فیلتر نتایج به سال:
An N-heterocyclic carbene (NHC)-catalyzed annulation reaction of isatin N-Boc ketimines and enals is developed for the synthesis of spirocyclic oxindole-γ-lactams bearing one quaternary chiral center in good yields and excellent stereoselectivities (up to >20:1 dr and 99% ee).
Isatin (1H-indole-2,3-dione) and its derivatives are responsible for a broad spectrum of biological activities. Among these the cytotoxic and antineoplastic properties have been the most widely reported. The synthetic versatility of the isatin, due to its privileged scaffold, has led to the generation of a large number of structurally diverse derivatives which include analogues derived from eit...
An isocratic analytical method based on liquid chromatographic determination with UV detection is described for the determination of isatin in spiked plasma and in its synthetic mixture. The separation of the isatin was achieved on a betasil C-8 column using a mobile phase consisting of a binary mixture of acetonitrile and buffer (Na2CO3 + NaHCO3). The linearity, accuracy and precision were fou...
The amyloid-β peptide is considered as a key player in the development and progression of Alzheimer's disease (AD). Although good evidence exists that amyloid-β accumulates inside cells, intracellular brain amyloid-binding proteins remain poorly characterized. Proteomic profiling of rat brain homogenates, performed in this study, resulted in identification of 89 individual intracellular amyloid...
Isatin is an endogenous indole in mammalian tissues and fluids that is expected to have antitumor effects in human breast cancer cells. Human breast cancer cells (MCF-7) were exposed to isatin at various concentrations (0, 50, 100, 200 µmol/l) for 48 h. Apoptotic features were demonstrated by nuclei staining with Hoechst 33258 and flow cytometry. Bcl-2 and Bax mRNA were analyzed via reverse tra...
A highly enantioselective aza-Henry reaction with isatin N-Boc ketimines using a Cu(II)-BOX complex as a catalyst is described. The reaction, which does not require protection of the N1 atom, provides the corresponding nitroamines bearing a quaternary stereocentre with high yields and enantiomeric excesses (up to 99.9%).
The title compound, C(13)H(15)NO(3), was synthesized by the Aldol reaction of isatin and 3-methyl-butan-2-one refluxing in methanol catalyzed by dimethyl-amine. The packing of the mol-ecules in the crystal structure features inter-molecular N-H⋯O and O-H⋯O hydrogen bonds.
In the title compound, C(16)H(13)N(5)O(3)S·CH(4)O, the dihedral angle between the isatin unit and the 2-methyl-phenyl group is 41.81 (2)° and intra-molecular N-H⋯O and N-H⋯N hydrogen bonds occur, generating S(6) and S(5) rings, respectively. In the crystal, polymeric chains arise as a result of N-H⋯O, O-H⋯S and C-H⋯O inter-actions.
A series of functionalized spiro[indoline-3,2'-oxiran]-2-ones was efficiently synthesized by Darzens reaction of phenacyl bromides with isatins both with N-alkyl groups and without N-substituent in the presence of potassium carbonate as a base catalyst. When two equivalents phenacyl bromides were used in the reaction, the N-substitution reaction of isatin also finished with the formation of spi...
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