Natural killer (NK) cells are considered to be key players in the early innate responses to protozoan infections, primarily indirectly by producing gamma interferon (IFN-gamma) in response to cytokines, like interleukin 12 (IL-12). We demonstrate that live, as well as heat-inactivated, tachyzoites of Neospora caninum, a Toxoplasma-like protozoan, directly trigger production of IFN-gamma from pu...

The tachyzoite stage of the protozoan parasite Toxoplasma gondii has two populations of microtubules: spindle microtubules and subpellicular microtubules. To determine how these two microtubule populations are regulated, we investigated microtubule behavior during the cell cycle following treatment with microtubule-disrupting drugs. Previous work had established that the microtubule populations...

Oral-route infection with Toxoplasma gondii sporozoites or tachyzoites leads to the rapid spread of quick-replicating cytolytic tachyzoites throughout the whole body. Toxoplasma easily crosses the blood-retina, encephalic and placental barriers. The acute phase of this infection lasts for less than around ten days. The parasite causes a very strong type-1 response focused on the interferon-gamm...

Toxoplasma gondii infection was diagnosed in a full term stillborn reindeer (Rangifer tarandus) fetus. The fetus had encephalitis and placentitis associated with T. gondii. Tissue cysts were identified histologically in sections of brain and tachyzoites were present in placenta and the myocardium. Protozoa in the brain, heart, and placenta stained positively with T. gondii antibodies, but not w...

By using stage-specific monoclonal antibodies, an in vitro model has been developed to analyze the kinetics of expression of stage-specific antigens during the conversion process between tachyzoites and bradyzoites of Toxoplasma gondii. Following infection of murine macrophages with bradyzoites, the expression of bradyzoite-specific antigens declined, whereas the expression of tachyzoite-specif...

the results of researches in the field of the using x-ray in all over the world have been successful. the main subject which needs more investigation and have been allocated part of the researches in most of the atomic research institutes, is the research about possible harms of irradiated food for human beings, base on the researches, using irradiation for inhibition of sprouting and preservat...

background: photoreactivation of microorganisms following uv disinfection is a disadvantage of using uv technology for wastewater treatment, since in some cases it may even reach several logarithms. the aim of this study was to evaluate the possibility of the photoreactivation of indicator bacteria (coliform and streptococci) in the irradiated effluent. methods: this study was performed using t...

Toxoplasma gondii Using cutting-edge cryo-cellular tomography technology, detailed molecular anatomy of gondii, particularly during the budding endodyogeny stage tachyzoites, is shown in article number 2206595 for first time. Based on these, Qiang Guo and co-workers propose that conoid fiber, a vital component conoid, may have microtubule origins.