An important exception to improvements in the relative socioeconomic status of blacks during recent decades is increased levels of joblessness among black youths relative to whites. Despite the many proposed explanations for this trend) few reconcile worsening employment status for black youths with concomitant improvements in other socioeconomic indicators. Three mechanisms that link reduced s...

The maintenance of the secretory response requires a continuous replenishment releasable vesicles. It was proposed that immediately pool (IRP) is important in chromaffin cell secretion during action potentials applied at basal physiological frequencies, because proximity IRP vesicles to voltage dependent Ca2+ channels. However, previous reports showed after depletion too slow manage such situat...

Chlamydia trachomatis (CT) is the leading cause of diseases related to reproductive health and iron plays important role in chlamydial pathogenesis. Iron homeostasis in chlamydia-infected cells is not clear thus far. This study shows that expression of the transferrin receptor (TfR) is downregulated, whereas expression of the ferritin heavy chain is upregulated in CT-infected HeLa-229 cells. Ex...

OBJECTIVE To analyze outcomes in children with intestinal failure treated by our Intestinal Rehabilitation Program (IRP) in a 4-year period. PATIENTS AND METHODS A total of 51 parenteral nutrition (PN)-dependent patients (20 male) were enrolled in the IRP. Median age was 1.7 years, with the primary diagnoses being gastroschisis, necrotizing enterocolitis, volvulus, and congenital atresia. Med...

Measurements of pupillary reactivity and size were recorded using neutral density filters and infrared pupillometry (IRP) in a prospective masked study of acute central retinal vein occlusion (CRVO) to quantify the two methods of measurement and to compare their value in the prediction of rubeosis. Thirty two patients were examined within 45 days of disease onset. The mean relative afferent pup...

The design of a supply chain has been considered by many practitioners and researchers recently. One model that is used to optimize distribution from a single facility (depot) to a set of retailers over a given planning horizon and considering stock management decisions is known as Inventory Routing Problem (IRP). This model tries to optimize the trade-off between inventory and transportation c...

Previously, we described a group of patients with hemocytopenia who did not conform to diagnostic criteria of known hematological and nonhematological diseases. Most patients responded well to adrenocortical hormone and/or high-dose intravenous immunoglobulin treatment, indicating that cytopenia might be mediated by autoantibodies. Autoantibodies were detected on the membrane of various bone ma...

Posttranscriptional regulation of genes of mammalian iron metabolism is mediated by the interaction of iron regulatory proteins (IRPs) with RNA stem-loop sequence elements known as iron-responsive elements (IREs). There are two identified IRPs, IRP1 and IRP2, each of which binds consensus IREs present in eukaryotic transcripts with equal affinity. Site-directed mutagenesis of IRP1 and IRP2 reve...

Anticancer therapy with doxorubicin (DOX) is limited by severe cardiotoxicity, presumably reflecting the intramyocardial formation of drug metabolites that alter cell constituents and functions. In a previous study, we showed that NADPH-supplemented cytosolic fractions from human myocardial samples can enzymatically reduce a carbonyl group in the side chain of DOX, yielding a secondary alcohol ...