In the study presented here, the iron status in the kidney in passive Heymann nephritis, a complement-dependent model of membranous nephropathy, was examined. To examine whether the effect of immune injury on iron status has a pathogenic role, the effect of an iron-deficient diet was also determined. Injection of the anti-Fx1A antibody (10 mg/100 g body wt) in Sprague-Dawley rats resulted in no...

Traditionally the iron status of a population is assessed by estimating the prevalence of iron deficiency anemia. This approach is inadequate in countries where the diet is heavily fortified with iron because it conveys no information about the iron-replete segment of the population. In the present study iron status of a US adult population was evaluated using data collected in the second Natio...

BACKGROUND Dietary studies show a relationship between the intake of iron enhancers and inhibitors and iron stores in the general population. However, the impact of dietary factors on the iron stores of blood donors, whose iron status is affected by blood donations, is incompletely understood. STUDY DESIGN AND METHODS In the Danish Blood Donor Study, we assessed the effect of blood donation f...

Women of reproductive age are at a high risk of iron deficiency, often as a result of diets low in bioavailable iron. In some settings, the iron content of domestic groundwater sources is high, yet its contribution to iron intake and status has not been examined. In a rural Bangladeshi population of women deficient in dietary iron, we evaluated the association between groundwater iron intake an...

An adequate supply of iron is essential for normal development of the fetus and newborn child. Iron deficiency and iron deficiency anemia (IDA) during pregnancy increase the risk of preterm birth and low birth weight. Iron is important for development of the fetal brain and cognitive abilities of the newborn. Children born to iron-deficient mothers will start their lives suffering from iron def...

We investigated the relation between maternal anaemia and neonatal iron status in 97 mothers and their babies. Haemoglobin (Hb), serum iron, total iron binding capacity and serum ferritin were determined. Mothers were divided into 3 groups: iron-deficient anaemic (22.7%), non-anaemic iron-deficient (27.8%) and non-anaemic non-iron-deficient (49.5%). There was no significant difference in the me...

Maternal iron status is thought to be related to postpartum depressive symptoms. The purpose of the present study was to evaluate the relationship between pre- and postnatal maternal iron status and depressive symptoms in pilot (n = 137) and confirmatory (n = 567) samples of Chinese women. Iron status was evaluated at mid- and late pregnancy and 3 days postpartum. The Edinburgh Postnatal Depres...

BACKGROUND Large genome-wide association (GWA) studies of European ancestry individuals have identified multiple genetic variants influencing iron status. Studies on the generalizability of these associations to African ancestry populations have been limited. These studies are important given interethnic differences in iron status and the disproportionate burden of iron deficiency among African...

BACKGROUND AND OBJECTIVES To assess the distribution of serum ferritin, serum soluble transferrin receptor and body iron among girls and women by age and anaemia. METHODS AND STUDY DESIGN Serum ferritin, serum soluble transferrin receptor and high sensitive C-reactive protein of 1625 and 1372 women in general and anaemic were measured in the National Health and Nutrition Survey commenced in 2...