PURPOSE The purpose of this study was to investigate the effect of the von Hippel-Lindau (VHL) protein on VEGF gene expression in vitro and to determine whether adenovirus-mediated VHL intraocular gene transfer inhibits the development of angiogenesis in a monkey model of multiple branch retinal vein occlusion (BRVO). METHODS A recombinant adenovirus vector adVHL was constructed to deliver th...

A female presented to the eye outpatient department with the chief complaint of blurred vision, pain, and redness in the left eye for 2 days. Visual acuity in the right eye was 6/6 and hand movement close to face in the left eye. Slit lamp examination left eye revealed a superior hypopyon, +3 cells in the anterior chamber, and iris neovascularization [Figures 1 and 2]. Intraocular pressure by n...

PURPOSE To explore the in vivo anti-angiogenesis effects resulting from lentivirus-mediated RNAi of vascular endothelial growth factor (VEGF) in monkeys with iris neovascularization (INV). METHODS Five specific recombinant lentiviral vectors for RNA interference, targeting Macaca mulatta VEGFA, were designed and the one with best knock down efficacy (LV-GFP-VEGFi1) in H1299 cells and RF/6A ce...

Branch retinal artery occlusion (BRAO) and branch retinal vein occlusion (BRVO) rarely cause neovascular glaucoma (NVG). A 58-year-old woman with hypertension and type 2 diabetic mellitus complained of progressive visual loss in her right eye for the previous 3 months. At initial examination, visual acuity was 20 / 63 in the right eye. Angle neovascularization was observed and the intraocular p...

PURPOSE To report a case of anterior segment ischemia (ASI) with rubeosis iridis after circular buckling surgery in a highly-myopic patient which was successfully treated with a second intravitreal bevacizumab injection. METHODS Case report and review of the literature. DISCUSSION ASI is a rare but potentially serious complication of posterior segment surgery. Finally it leads to neovascula...

Uveitis-Glaucoma-Hyphaema Syndrome (UGH syndrome, or "Ellingson" Syndrome) is a rare condition caused by the mechanical trauma of an intraocular lens malpositioned over adjacent structures (iris, ciliary body, iridocorneal angle), leading to a spectrum of iris transillumination defects, microhyphaemas and pigmentary dispersion, concomitant with elevated intraocular pressure (IOP). UGH Syndrome ...

PURPOSE To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 (103Pd) plaque brachytherapy. DESIGN Retrospective, nonrandomized, interventional case series. PARTICIPANTS Fifty patients with primary malignant melanoma of the iris. METHODS Palladium-103 plaque brachytherapy. MAIN OUTCOME MEASURES Changes in tumor size, pigmentation, and vascularity; in...

A patient is reported in whom the clinical observation of extension of the corneal endothelium and Descemet's membrane in association with rubeosis iridis was confirmed by histopathological examination. In a study of eyes which had been removed and demonstrated rubeosis iridis and secondary glaucoma in 16 additional eyes revealed extension of the corneal endothelium and Descemet's membrane on t...

Neovascular glaucoma is a challenging disease in its pathogenesis and treatment. Ischemic retinopathies can lead to neovascular glaucoma due to newly formed vessels on the iris surface and anterior chamber angle. Eyes with neovascular glaucoma can exhibit high intraocular pressure, usually treated by retinal coagulation, cyclodestructive procedures, or drainage procedures. Based on experimental...