نتایج جستجو برای: irbesartan

تعداد نتایج: 849  

Journal: :Cardiovascular Diabetology 2007
Klaus G Parhofer Felix Münzel Michael Krekler

AIMS A number of intervention studies have shown that therapy with angiotensin receptor blockers, such as irbesartan, can improve metabolic parameters and reduce the incidence of diabetes mellitus. It is unknown whether this observation also holds true in routine clinical settings. METHODS We evaluated the effect of irbesartan (150 mg or 300 mg/d) together with or without hydrochlorothiazide ...

2015
Hatice Odabas İlyas Capoglu Ramazan Cetinkaya Ali Riza Odabas Abdullah Uyanik Mustafa Keles

Purpose: To investigate the dual effect of angiotensin blockade by irbesartan and enalapril on proteinuria in diabetic patients with azotemia. Methods: Patients with diabetes of > 5 years duration, proteinuria at a nephrotic level and serum creatinine > 1.5 mg/dL were enrolled in the study. Forty-five enrolled patients were divided into three groups, those receiving enalapril , irbesartan, or e...

Journal: :Circulation 2010
Michael R Zile William H Gaasch Inder S Anand Markus Haass William C Little Alan B Miller Jose Lopez-Sendon John R Teerlink Michel White John J McMurray Michel Komajda Robert McKelvie Agata Ptaszynska Scott J Hetzel Barry M Massie Peter E Carson

BACKGROUND The mode of death has been well characterized in patients with heart failure and a reduced ejection fraction; however, less is known about the mode of death in patients with heart failure and a preserved ejection fraction (HFPEF). The purpose of this study was to examine the mode of death in patients with HFPEF enrolled in the Irbesartan in Heart Failure With Preserved Ejection Fract...

2010
Sten Andersen Harald Mischak Petra Zürbig Hans-Henrik Parving Peter Rossing

BACKGROUND Previously the angiotensin II receptor blocker Irbesartan has been demonstrated to reduce the risk for progression from microalbuminuria to macroalbuminuria in type 2 diabetic patients. The purpose of this study was to evaluate the effect of treatment with Irbesartan in type 2 diabetic patients with microalbuminuria on the urinary proteome. METHODS High-resolution capillary-electro...

Journal: :American journal of hypertension 2005
Guillaume Bobrie Jean Delonca Cyril Moulin Alain Giacomino Nicolas Postel-Vinay Roland Asmar

BACKGROUND The objective of this prospective, randomized, open-label, blinded-endpoint study was to compare the antihypertensive efficacy of valsartan 80 mg v irbesartan 150 mg when combined with hydrochlorothiazide (HCTZ) 12.5 mg. METHODS Untreated or uncontrolled hypertensive adults (n = 800) were enrolled by primary care physicians. After a 5-week open-label lead-in phase in which all pati...

2014
Enrico Agabiti-Rosei Athanasios Manolis Dario Zava Stefano Omboni

INTRODUCTION In most treated patients with hypertension, a two or more drug combination is required to achieve adequate blood pressure (BP) control. In our study we assessed whether the combination of zofenopril + hydrochlorothiazide (HCTZ) was at least as effective as irbesartan + HCTZ in essential hypertensives with at least one additional cardiovascular risk factor, uncontrolled by a previou...

2009
Frederik Persson Peter Rossing Henrik Reinhard Tina Juhl Coen D.A. Stehouwer Casper Schalkwijk A.H. Jan Danser Frans Boomsma Erik Frandsen Hans-Henrik Parving

OBJECTIVE We investigated whether the antiproteinuric effect of the direct renin inhibitor aliskiren is comparable to that of irbesartan and the effect of the combination. RESEARCH DESIGN AND METHODS This was a double-blind, randomized, crossover trial. After a 1-month washout period, 26 patients with type 2 diabetes, hypertension, and albuminuria (>100 mg/day) were randomly assigned to four ...

Journal: :Cardiovascular journal of Africa 2009

The addition of irbesartan to the treatment of normotensive patients with atrial fibrillation in the ACTIVE-I study resulted in a significant reduction in hospitalisation for heart failure and an overall reduction in the number of days spent in hospital for any cardiovascular-related reason. While the increased risk of stroke is perhaps most feared in atrial fibrillation, heart failure is the ‘...

Journal: :Hypertension 2002
Paolo Mulatero Franco Rabbia Alberto Milan Cristina Paglieri Fulvio Morello Livio Chiandussi Franco Veglio

Primary aldosteronism is a specifically treatable and potentially curable form of secondary hypertension. The aldosterone/plasma renin activity ratio (ARR) is routinely used as a screening test. Antihypertensive therapy can interfere with the interpretation of this parameter, but a correct washout period can be potentially harmful. We have investigated the effects of therapy with atenolol, amlo...

Journal: :Respiratory investigation 2013
Junichi Tanaka Shunji Tajima Katsuaki Asakawa Takuro Sakagami Hiroshi Moriyama Toshinori Takada Eiichi Suzuki Ichiei Narita

BACKGROUND Idiopathic pulmonary fibrosis is a specific form of chronic fibrosing interstitial pneumonia that is limited to the lung. Angiotensin receptor blockers (ARBs) and peroxisome proliferator-activated receptor (PPAR) γ ligands have anti-inflammatory and anti-fibrotic effects. We investigated the effects of irbesartan-an ARB with PPAR γ activity-on the development of bleomycin-induced pul...

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