This study is to identity the clinical characteristics of mydriasis derived from nebulized ipratropium bromide in neurosurgical patients. We presented 3 patients with inhalation of ipratropium bromide associated mydriasis and reviewed the pertinent literature. Mydriasis was caused by nebulized ipratropium bromide leak from the mask into ipsilateral eye. When the medication was discontinued in t...

BACKGROUND In acute severe asthma, treatment must be initiated early to reverse the pathophysiology that may render airways less responsive to bronchodilation. The addition of nebulized ipratropium bromide to initial emergency department therapy improves pulmonary function, but it is unclear whether this approach results in earlier hospital discharge. The early use of bolus intravenous salbutam...

In a double blind randomised trial, we found no evidence that nebulised ipratropium bromide was of clinical benefit in acute bronchiolitis.

this is a clinical trial regarding the comparative effect of two drugs in copd patients. the drugs were salbutamol and ipratropoim bromide that are being used commonly in the treatment of copd. salbotamol is less expensive in iran and more available than ipratropim. we chose 16 patients which were referred to pulmonary clinic in imamhospital, sari. the pulmonary function test was done for each ...

Aclidinium bromide is a novel potent, long-acting inhaled muscarinic antagonist in development for the treatment of chronic obstructive pulmonary disease. Aclidinium showed subnanomolar affinity for the five human muscarinic receptors (M(1)-M(5)). [(3)H]Aclidinium dissociated slightly faster from M(2) and M(3) receptors than [(3)H]tiotropium but much more slowly than [(3)H]ipratropium. Its asso...

AIMS B2-agonists and anticholinergic drugs may alter cardiac autonomic modulation. The aim of this study was to investigate the effects of inhaled salbutamol and ipratropium bromide on heart rate variability (HRV). METHODS AND RESULTS A randomized, double-blind, crossover design study was conducted on 13 healthy volunteers. Salbutamol, ipratropium or placebo was administered in three differen...

The dose-response relationships of the anticholinergic bronchodilator drug ipratropium bromide were studied. Cumulative doses totalling 288 micrograms ipratropium were given by inhalation of a liquid aerosol from a Wright nebuliser to each of 10 patients with stable, moderately severe airflow obstruction. Up to 80% of the maximum achievable bronchodilator response, as assessed by a rise in the ...

The effects of three different regimens of inhaled bronchodilators on spirometry and respiratory impedance as measured with the technique of forced oscillations were compared in a double-blind crossover study in 22 patients with stable chronic obstructive pulmonary disease (FEV1 less than 70 percent predicted). On three trial days, patients inhaled, in random order, 40 micrograms ipratropium br...

Regular exposure to antimuscarinic drugs would be expected to upregulate airway muscarinic receptors and could cause a transient increase in airways obstruction if treatment was stopped or omitted. We have examined peak expiratory flow rate (PEFR) during treatment and forced expiratory flow in one second (FEV1) and airway responsiveness to three constrictor agonists (as the provocative dose of ...

Amaç: Anizokori, hayatı tehdit eden kafa içi hadiselerin ilk habercisi olabileceği gibi, sık kullanılan ilaçların yan etkisi olarak da karşımıza çıkabilir. Atropin, skopolamin, amfetamin gibi farmakolojik ajanların sistemik kullanımı genellikle bilateral midriazise yol açarken, nebulizatör ile ipratropium bromürün göze direkt teması tek taraflı midriazis izlenebilir. Bu yazıda, ajana bağlı aniz...