ecause cervical cancer has few subjective symptoms, and progression to invasive cancer is slow, early detection of precancerous lesions by screening is important for prevention. It is globally acknowledged that the prevalence of cervical cancer screening as a secondary prevention is effective for reducing the incidence of cervical cancer and mortality. However, adherence with the recommended sc...

PURPOSE The purposes of the study were (1). to assess the cost-effectiveness of three interventions to deliver breast and cervical cancer screening to women unscreened for >or=3 years and (2). to determine the relation of an invasive cervical cancer diagnosis to the interval since the last true screening test. METHODS In a randomized trial, women were randomly assigned to (1). usual care, (2)...

BACKGROUND The association between HIV infection and invasive cervical cancer that has been reported may reflect differential prevalence of human papillomavirus (HPV) infection or uncontrolled confounding. We conducted a case-control study in a West African population to assess the relationship between HIV infection and invasive cervical cancer, taking into account HPV infection and other poten...

AIM To determine the prevalence of high-grade cervical lesion (CIN 2 or worse, CIN 2+) and the prevalence of invasive cancers in women with LSIL, HSIL and positive for malignancy on cytology, respectively. METHODS A retrospective study of patients undergoing colposcopy in Rajavithi hospital between 2003-2004 was performed. The final diagnosis was based on colposcopy and histology. RESULTS A...

Cervical cancer is the second leading cause of cancer mortality in women worldwide, and the leading cause in Africa. There is uncertainty in the role of HIV infection as a risk factor for invasive and preinvasive cervical lesions, particularly in African populations. In a case-control study in Dakar, Senegal, we studied 150 women with invasive cervical cancer (ICC), 92 with cervical intraepithe...

BACKGROUND Currently, available data regarding previous cervical cytology and high-risk human papillomavirus (hrHPV) test results to detect invasive cervical cancer are limited and controversial in China. Therefore, this retrospective study in a population of Chinese women with invasive cervical carcinoma aimed to gain further insight into the roles of cytology and hrHPV testing in cervical can...

Cervical cancer is the second leading cause of death from cancer in women worldwide, and recent epidemiological studies have strongly implicated the sexually transmitted human papillomavirus (HPV) as a causative agent. The ability of high-risk HPVs to contribute to malignant progression seems to depend on expression of the viral E6 and E7 oncogenes. The E6 oncoprotein forms a complex with the c...

Despite worldwide human papillomavirus (HPV) types distribution showed constant rates of HPV 16/18 in cervical cancers, regional variations have been consistently documented. Very little data is available on HPV genotype prevalence among Italian women with invasive cervical cancer. This study aims to determine the HPV type distribution in cervical specimens obtained from Italian women diagnosed...

Membrane type 1 matrix metalloproteinase (MT1-MMP) is frequently expressed by cancer cells and is believed to play an important role in cancer cell invasion and metastasis. However, little is known about the role of MT1-MMP in mediating invasiveness of cervical cancer cells. In this study, we examined MT1-MMP expression in 58 primary human cervical tissue specimens, including normal cervix, low...

Cervical cancer is the most common gynecologic malignancy in Taiwan. The incidence of cervical cancer is 51.88/100,000 women in 20021. Over 99% of cervical cancers are caused by the high-risk group of human papillomavirus (HPV)2, which includes types 16 and 18 that are responsible for over 70% of cervical cancer. Quadrivalent (Gardasil®; Merck & Co., NJ, USA) and bivalent (Cervarix®; GlaxoSmith...