Intrinsic plasticity (IP) is a ubiquitous activity-dependent process regulating neuronal excitability and a cellular correlate of behavioral learning and neuronal homeostasis. Because IP is induced rapidly and maintained long-term, it likely represents a major determinant of adaptive collective neuronal dynamics. However, assessing the exact impact of IP has remained elusive. Indeed, it is extr...

The response of a neuronal population over a space of inputs depends on the intrinsic properties of its constituent neurons. Two main modes of single neuron dynamics-integration and resonance-have been distinguished. While resonator cell types exist in a variety of brain areas, few models incorporate this feature and fewer have investigated its effects. To understand better how a resonator's fr...

The intrinsic rate of increase is a basic parameter which an ecologist may wish to establish for an insect population. We define it as the rate of increase per head under specified physical conditions, in an unlimited environment where the effects of increasing density do not need to be considered. The growth of such a population is by definition exponential. Many authors, including Malthus and...

Two hormones from the gastrointestinal tract, glucagon and oxyntomodulin (OXM), vigorously elevate the intrinsic heart rate (IHR) of mice. We have previously shown that OXM influences murine heart rate (HR) independent of the glucagon-like peptide 1 (GLP-1) receptor. Here, we demonstrate using radiotelemetry in mice deficient in the glucagon receptor (Gcgr -/-) that both OXM and glucagon requir...

In reviewing the article “Methemoglobinemia: Sudden Dyspnea and Oxygen Desaturation After Esophagoduodenoscopy,” in the August 2004 issue of RESPIRATORY CARE,1 I found the article suggested that, during the esophagoduodenoscopy procedure the patient’s blood oxygen saturation (measured via pulse oximetry) began to drop rapidly, and a saturation of 54% registered on the pulse oximeter while the p...

We have compiled a sample of 45 Type Ia supernovae (SNe Ia) discovered by the Lick Observatory Supernova Search (LOSS) and the Beijing Astronomical Observatory Supernova Survey (BAOSS), and determined the rate of spectroscopically peculiar SNe Ia (i.e., SN 1986G-like, SN 1991bg-like, and SN 1991T-like objects) and the luminosity function of SNe Ia. Because of the nature of the two surveys (dist...

Co-amorphous systems is one of the attractive strategies used to enhance the dissolution rates of poorly soluble drugs. This strategy has an additional advantage as it has the ability to overcome stability issues that may arise from the conversion of a crystalline drug into its amorphous form. In this study, quench cooling was used to prepare co-amorphous forms of carbamazepine (CBZ) with sacch...

Intrinsic rate constants play a dominant role in the theory of diffusion-influenced reactions, but usually as abstract quantities that are implicitly assumed to be known. However, recently it has become clear that modeling complex processes requires explicit knowledge of these intrinsic rates. In this paper we provide microscopic expressions for the intrinsic rate constants for association and ...