PURPOSE Previous reports have identified noninfectious uveitis as a potential sequela following both intravitreal bevacizumab and ranibizumab injections. We present two unique cases of acute anterior uveitis following intravitreal bevacizumab that did not occur with subsequent ranibizumab injections. METHODS Case report. CONCLUSION These cases may reflect differences in the etiology of ante...

PURPOSE To evaluate dexamethasone pharmacokinetics after implantation of a sustained-release dexamethasone (DEX) intravitreal implant in nonvitrectomized and vitrectomized eyes. METHODS The right eyes of 25 rabbits underwent vitrectomy; contralateral eyes served as nonvitrectomy controls. The 0.7-mg DEX implant was injected into both eyes, and drug concentrations were determined in the vitreo...

BACKGROUND The purpose of this study was to evaluate the angiographic results of retinal-retinal anastomosis (RRA) and retinal-choroidal anastomosis (RCA) for eyes with retinal angiomatous proliferation (RAP) after treatment with intravitreal bevacizumab injections as monotherapy or intravitreal bevacizumab combined with photodynamic therapy. METHODS In this interventional, consecutive case s...

Ophthalmic drug delivery to the posterior segment of eye has been challenging due complex ocular anatomy. Intravitreal injection drugs was introduced deliver therapeutic doses in segment. Different diseases including age-related macular degeneration, diabetic edema, retinal vein occlusions, uveitis, and cystoid among others, have historically treated with intravitreal corticosteroids injections...

This article describes how to give an intravitreal injection of an anti-VEGF drug. At present, the majority of intravitreal injections are administered by doctors; however, experience in the UK has shown that trained nurses can give these injections as safely as ophthalmologists. The single most important thing to remember is that an intravitreal injection is an intraocular operation, and shoul...

BACKGROUND The purpose of this study was to evaluate the safety of intravitreal ranibizumab injection in patients with age-related macular degeneration. MATERIALS AND METHODS We examined retinal ganglion cell function using the photopic negative response of the electroretinogram (ERG) in patients with age-related macular degeneration (AMD) treated with intravitreal injections of ranibizumab. ...

BACKGROUND Corticosteroids play a major role in the treatment of many diseases of the posterior ocular segment. Systemically or topically administered steroids usually do not attain therapeutic concentrations in the retina, as they must first cross the blood-retina barrier. Intravitreal application is a useful alternative means of achieving therapeutic concentrations in the posterior segment bu...

BACKGROUND Cytomegalovirus (CMV) retinitis is an opportunistic infection that primarily affects immunocompromised individuals. Intravitreal ganciclovir injection monotherapy or in combination with systemic anti-CMV therapy are effective treatments for CMV retinitis. Crystallization of ganciclovir after intravitreal injection is extremely rare. Only two cases had been reported in literature. Cry...

PURPOSE to report a case of severe ocular hypertension occurring as a complication after a single intravitreal injection of triamcinolone acetonide for the treatment of a diabetic cystoid macular edema. METHODS interventional case report. RESULTS a 63-year-old pseudophakic diabetic woman developed a severe and relatively sudden IOP increase to 50 mm Hg one month after receiving a single 4-m...

PURPOSE To evaluate the changes in intraocular pressure (IOP) after intravitreal injection of triamcinolone acetonide for the management of diabetic macular edema (DME). METHODS The study design is a prospective, interventional, two-arm, dose-response study. Nineteen patients with bilateral DME were included, one eye for every patient underwent intravitreal injection of 4 mg triamcinolone ace...