This narrative review summarizes the role of vitamin C in mitigating oxidative injury-induced microcirculatory impairment and associated organ failure in ischemia/reperfusion or sepsis. Preclinical studies show that high-dose vitamin C can prevent or restore microcirculatory flow impairment by inhibiting activation of nicotinamide adenine dinucleotide phosphate-oxidase and inducible nitric oxid...

background: hepatitis c (hcv) is increasing worldwide including iran. hcv is more prevalent among intravenous drug abusers (idu), especially if imprisoned, mostly due to needle sharing. we determined the rate of hcv seropositivity among idu prisoners and compared it with those of non prisoners. materials and methods: a cross-sectional survey was done on consenting idu inhabiting two prisons and...

This case report summarizes the first use of intravenous vitamin C employed as an adjunctive interventional agent in the therapy of recurrent acute respiratory distress syndrome (ARDS). The two episodes of ARDS occurred in a young female patient with Cronkhite-Canada syndrome, a rare, sporadically occurring, noninherited disorder that is characterized by extensive gastrointestinal polyposis and...

In our case the clinical and temporal profile of the illness along with MRI findings were highly suggestive of TSP. Various treatment modalities like steroid, interferon-a, vitamin C, zidovudine, azathioprine, cyclophosphamide, IVIg have been tried but results are largely disappointing.3 The absence of serological evidence of HTLV infection may be due to infection by other viruses, nutritional ...

Patients with chronic obstructive pulmonary disease (COPD) have decreased ventilatory and cerebrovascular responses to hypercapnia. Antioxidants increase the ventilatory response to hypercapnia in healthy humans. Cerebral blood flow is an important determinant of carbon dioxide/hydrogen ion concentration at the central chemoreceptors and may be affected by antioxidants. It is unknown whether an...