Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal al...

The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formula...

Bovine respiratory syncytial virus (BRSV) infects cells of the respiratory mucosa, so it is desirable to develop a vaccination strategy that induces mucosal immunity. To achieve this, various delivery routes were compared for formalin-inactivated (FI) BRSV formulated with CpG oligodeoxynucleotide (ODN) and polyphosphazene (PP). Intranasal delivery of the FI-BRSV formulation was superior to subc...

BACKGROUND We hypothesized that SRX246, a vasopressin V1a receptor antagonist, blocks the effect of intranasally administered vasopressin on brain processing of angry Ekman faces. An interaction of intranasal and oral drug was predicted in the amygdala. METHODS Twenty-nine healthy male subjects received a baseline fMRI scan while they viewed angry faces and then were randomized to receive ora...

INTRODUCTION Intranasal meningoceles occur as a result of herniation of the meninges into the nasal cavity through a defect in the cribriform plate. These are commonly found in the pediatric population due to a congenital defect in the skull base. Intranasal meningoceles are very rare in adults, and tend to arise only when engendered by trauma. Here, we present the case of a patient with seemin...

OBJECTIVE To examine use of the paramedian forehead flap for intranasal lining. METHODS The medical records and photographs were reviewed for patients who underwent a nasal reconstruction involving a paramedian forehead flap used for internal lining. RESULTS Three patients underwent this procedure. In all patients, the flap provided excellent intranasal lining. External incisions were accep...

although response to intranasal steroid therapy has been reported in pa¬tients with allergic rhinitis, efficacy of some nasal steroids is noteworthy. this study was undertaken to evaluate the efficacy of a two-week course of fluticasone (flixonase) nasal spray vs. beclomethasone (beconase) nasal spray in patients with symptoms of allergic rhinitis referred to our clinic. this study reviewed six...

The goal of brain drug targeting technology is the delivery therapeutics across blood barrier (BBB), including human BBB. Nose to has received a great deal attention as non- invasive, convenient and reliable system. For systemic targetedadministration drug. various deliveries through some transport pathways, Factor influencing nasal absorption, formulation strategies nose brain, colloidal carri...

Oxytocin has been implicated in a variety of prosocial processes but most of this work has used laboratory tasks (such as the ultimatum game or the dictator game) to evaluate oxytocin's prosocial effects. In a double blind randomized trial we examined the influence of intranasal administration of oxytocin on real, high-cost donating money to a charity without any expectation for reciprocation. ...

BACKGROUND AND AIMS Preprocedural preparation of children scheduled for magnetic resonance imaging (MRI) is challenging. This prospective, randomized trial compared intranasal midazolam with intranasal dexmedetomidine as premedication for children scheduled for brain MRI. MATERIAL AND METHODS In total, 60 children, aged 1-8 years, scheduled for elective brain MRI, were randomly assigned to th...