نتایج جستجو برای: intramolecular michael addition

تعداد نتایج: 747019  

Journal: :Chemical synthesis 2023

We report herein an enantioselective acyl transfer protocol via electrophile activation. The reaction cascade sequence encompasses dinuclear zinc-catalyzed asymmetric Michael addition, intramolecular cyclization, and retro-Claisen reaction, which leads to a step- atom-economic approach variety of protected cyclic tertiary α-hydroxyketones in good yields with excellent enantioselectivities (24 e...

Journal: :Advanced Synthesis & Catalysis 2021

A transition-metal-free and base-promoted one-pot reaction of ynones with 2-aminobenzonitriles is described. The was initiated through sequential aza-Michael addition/intramolecular annulation to afford various multisubstituted 4-aminoquinolines 4-amino-1,8-naphthyridines in good excellent yields. Operational simplicity, high atom-economy broad substrate scope makes this protocol more attractiv...

Journal: :iranian journal of catalysis 2014
hossein eshghi mohammad rahimizadeh seyed mohsen mousavi

silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1h)-ones. this intramolecular aza michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. the catalyst is reusable without significant decreases in its activity after four t...

Journal: :The Journal of organic chemistry 2013
Eugene E Kwan Jonathan R Scheerer David A Evans

We present a general model for understanding the stereochemical course of intramolecular Michael reactions. We show that the addition of β-ketoester enolates to α,β-unsaturated esters and imides bearing adjacent stereocenters (X, Y = H, Me, OR) leads to high levels of asymmetric induction. Reinforcing and nonreinforcing stereochemical relationships are evaluated from the syn and anti reactant d...

2017
Vesa Rauhala Marta Nevalainen Ari M. P. Koskinen

A new short strategy to prepare the spiroketal fragment of calyculins is presented. A novel Seyferth–Gilbert type homologation of hindered lactols to the corresponding alkynes has been achieved for the first time. The spirocyclization was achieved efficiently via a DIHMA (double intramolecular hetero-Michael addition) process of this hindered ynone. The spirocyclization rate is not dependent on...

2016
Mohammad A. Alam Zakeyah Alsharif Hessa Alkhattabi Derika Jones Evan Delancey Adam Gottsponer Tianhong Yang

An efficient synthesis of novel 2,3-dihydro-4H-pyrido[1,2-a]pyrimidin-4-ones has been reported. Inexpensive and readily available substrates, environmentally benign reaction condition, and product formation up to quantitative yield are the key features of this methodology. Products are formed by the aza-Michael addition followed by intramolecular acyl substitution in a domino process. The polar...

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