intractable asthma is a challenging clinical problem. this study was conducted to determine whether a subset of patients with intractable asthma may be misdiagnosed and have a form of bronchiolitis instead and also to determine the effectiveness of macrolide therapy in these patients. seventy six patients with intractable asthma were re-treated with recommended maximal doses of oral prednisolon...

objective the lennox-gastaut syndrome (lgs), one of the most difficult epilepsy syndromes to treat, is characterized by a triad of intractable seizures of various types, a slow (< 2.5-hertz) spike-wave pattern in eeg and mental retardation. the aim of this study was to evaluate the efficacy and safety of lamotrigine as add-on therapy in intractable epilepsy of children with lgs. materials & met...