The purpose of this paper is to simulate the future runoff change Yellow River Basin under combined effect land use and climate based on Cellular automata (CA)-Markov Soil & Water Assessment Tool (SWAT). changes in average runoff, high extreme intra-annual distribution middle 21st century are analyzed. following conclusions obtained: (1) Compared with base period (1970–1990), Tangnaihai, To...

Activation of a host DNA damage response (DDR) is essential for DNA replication of minute virus of canines (MVC), a member of the genus Bocavirus of the Parvoviridae family; however, the mechanism by which DDR contributes to viral DNA replication is unknown. In the current study, we demonstrate that MVC infection triggers the intra-S-phase arrest to slow down host cellular DNA replication and t...

UNLABELLED Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular administration but has never been used in neonatal HI rats. AIMS In this st...

The design of a non-viral gene delivery system that can release functional nucleic acid at the intracellular destination site is an exciting but also challenging proposition. ideal vector must be non-toxic, non-immunogenic, overcome extra- and intra-cellular barriers, protect cargo from degradation with stability over range temperatures. A new 15 amino linear peptide termed CHAT was designed in...

Intra-operative diagnosis of brain tumours routinely employs frozen sections. The frozen section however has several limitations and induces serious freezing artefacts. We carried out a prospective study on 40 cases of astrocytomas utilizing touch preparation cytology. The smears were quite cellular with crisp cellular details. There was 98.4% sensitivity and 90% specificity. We found touch pre...