PURPOSE Specific chemokines and their respective receptors have been implicated in distant tumor cell metastasis. Cutaneous melanoma has a distinct pattern of metastasis, preferentially targeting the submucosa of the small intestine. However, the underlying pathogenic mechanism remains unknown. Migration of CCR9(+) lymphocytes to the small intestine is known to occur in response to the chemoatt...

BACKGROUND Gastro-Intestinal stromal tumours (GISTs) are rare and our understanding of their natural history and optimal treatment are continually evolving. Port site metastasis after laparoscopy for a GIST is an extremely rare phenomenon. CASE PRESENTATION We report a case with relevant imaging and discuss factors that may have contributed to the development of this isolated metastasis. CO...

Three cases of primary malignant lymphoma and primary mucus-secreting adenocarcinoma of the intestinal tract, occurring in the same patients, are described, and three similar cases reported in the literature are discussed. The carcinomas were present at the same time as the lymphomas, or developed after the lymphomas had been removed. The relationship between malignant lymphoma and carcinoma is...

BACKGROUND Ramucirumab is a monoclonal antibody targeting vascular endothelial growth factor receptor 2 (VEGFR-2). Ramucirumab either alone or in combination with paclitaxel (PTX) has been found to be safe and effective for patients with previously treated advanced gastric cancer. One of the serious adverse events associated with ramucirumab is gastrointestinal (GI) perforation. CASE PRESENTA...