New drug candidates increasingly tend to be poorly water soluble. One approach to increase their solubility is to convert the crystalline form of a drug into the amorphous form. Intrinsic dissolution testing is an efficient standard method to determine the intrinsic dissolution rate (IDR) of a drug and to test the potential dissolution advantage of the amorphous form. However, neither the Unite...

IDR(s) [9] and BiCGstab(l) [5] are two of the most efficient short recurrence iterative methods for solving large nonsymmetric linear systems of equations. Which of the two is best depends on the specific problem class. In this paper we derive a new method, that we call IDRstab, that that combines the strengths of IDR(s) and BiCGstab(l). To derive IDRstab we extend the results that we reported ...

IDPs, while structurally poor, are functionally rich by virtue of their flexibility and modularity. However, how mutations in IDPs elicit diseases, remain elusive. Herein, we have identified tumor suppressor PTEN as an intrinsically disordered protein (IDP) and elucidated the molecular principles by which its intrinsically disordered region (IDR) at the carboxyl-terminus (C-tail) executes its f...

Analytical seismic response of multi-story building supported on base isolation system is investigated under real earthquake motion. The superstructure is idealized as a shear type flexible building with lateral degree-of-freedom at each floor. The force-deformation behaviour of the isolation system is modelled by the bi-linear behaviour which can be effectively used to model all isolation syst...

Macrophages play a critical role in the innate immune response. To respond in a rapid and efficient manner to challenges in the micro-environment, macrophages are able to differentiate towards classically (M1) or alternatively (M2) activated phenotypes. Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defence peptides, have enhanced immunomodulatory activities...

The Induced Dimension Reduction method [12] was proposed in 1980 as an iterative method for solving large nonsymmetric linear systems of equations. IDR can be considered as the predecessor of methods like CGS (Conjugate Gradient Squared) [9]) and Bi-CGSTAB (Bi-Conjugate Gradients STABilized, [11]). All three methods are based on efficient short recurrences. An important similarity between the m...

OBJECTIVES This study aims to assess the value for money and budget impact of offering hemodialysis (HD) as a first-line treatment, or the HD-first policy, and the peritoneal dialysis (PD) first policy compared to a supportive care option in patients with end-stage renal disease (ESRD) in Indonesia. METHODS A Markov model-based economic evaluation was performed using local and international d...

The Induced Dimension Reduction method [12] was proposed in 1980 as an iterative method for solving large nonsymmetric linear systems of equations. IDR can be considered as the predecessor of methods like CGS (Conjugate Gradient Squared) [9]) and Bi-CGSTAB (Bi-Conjugate Gradients STABilized, [11]). All three methods are based on efficient short recurrences. An important similarity between the m...