The hypothesis that population pressure causes increased warfare has been recently criticized on the empirical grounds. Both studies focusing on specific historical societies and analyses of cross-cultural data fail to find positive correlation between population density and incidence of warfare. In this paper we argue that such negative results do not falsify the population-warfare hypothesis....

Myoglobin (Mb) binds diatomic ligands, like O2, CO, and NO, in a cavity that is only transiently accessible. Crystallography and molecular simulations show that the ligands can migrate through an extensive network of transiently connected cavities but disagree on the locations and occupancy of internal hydration sites. Here, we use water (2)H and (17)O magnetic relaxation dispersion (MRD) to ch...

Proteins have evolved to perform their targeted biochemical function precisely and efficiently. Growing evidence from experiments and computational approaches suggests an intimate synergy between an enzyme’s structure, intrinsic dynamics and biochemical function. In this thesis, we investigate the role of intrinsic dynamics in enzyme catalysis by developing novel theoretical and computational t...

We consider biofilaments-flexible multimolecule structures common in cell biology-and show how "internal" friction associated with either conformational fluctuations or with fluid flow through narrow pores inside the filaments can dominate the external hydrodynamic friction usually considered to be the main energy dissipation process. The signature of this is wave-number-independent relaxation ...

Stratified hydrostatic fluids have linear internal gravity waves with different phase speeds and vertical profiles. Here a simplified set of partial differential equations (PDE) is derived to represent the nonlinear dynamics of waves with different vertical profiles. The equations are derived by projecting the full nonlinear equations onto the vertical modes of two gravity waves, and the result...

The migration literature has identified the various mechanisms explaining why migration processes tend to gain their own momentum and become self-perpetuating partly independent of their original causes and migration policies. In particular the migration-facilitating role of migrant networks has been extensively studied. The current theoretical literature ascribes a pivotal role to networks in ...

This paper offers a revisionist account of the development of Mendelian genetics, focusing on the 'problem of the gene', 1900-1930. I examine conflicting claims about the composition, location, and action of genes posed by Bateson, the Morgan group, and Goldschmidt. Their research programs focused on different phenotypes and were based on different assumptions about the nature of genes. The pro...

Fights-to-the-death occur in many natural, medical and commercial settings. Standard mass action theory and conventional wisdom imply that the minority (i.e. smaller) group’s survival time decreases as its relative initial size decreases, in the absence of replenishment. Here we show that the opposite actually happens, if the minority group features internal network dynamics. Our analytic theor...

– We study the time-dependent height fluctuations of an active membrane containing energy-dissipating pumps that drive the membrane out of equilibrium. Unlike previous investigations based on models that neglect either curvature couplings or random fluctuations in pump activities, our formulation explores two new models that take both of these effects into account. In the first model, the magni...

A new approach for the study of social games and communications is proposed. Games are simulated between cognitive players who build the opponent's internal model and decide their next strategy from predictions based on the model. In this paper, internal models are constructed by the recurrent neural network (RNN), and the iterated prisoner's dilemma game is performed. The RNN allows us to expr...