background in some autoimmune diseases such as rheumatoid arthritis (ra), interleukin-27 (il-27) and il-33 levels are increased. these observations suggest that il-27 and il-33 may have a role in the pathogenesis of polymyositis/dermatomyositis (pm/dm). conclusions these data indicate that il-27 might be selectively involved in the pathogenesis of dm and pm. however, il-33 does not appear to be...

Interleukin-33 (IL-33) is a member of the IL-1 family and has dual functions as nuclear factor well cytokine. The pivotal role IL-33 an active player contributing to aberrant local systemic damage been highlighted in several inflammatory autoimmune diseases. Primary Sjogren's syndrome (pSS) disease characterized by dry eyes mouth due dysfunctions exocrine glands, but also accompanied with manif...