نتایج جستجو برای: interferon lambda 3

تعداد نتایج: 1887222  

2015
Jacques Friborg Petra Ross-Macdonald Jian Cao Ryan Willard Baiqing Lin Betsy Eggers Fiona McPhee

Peginterferon lambda-1a (Lambda), a type III interferon (IFN), acts through a unique receptor complex with limited cellular expression outside the liver which may result in a differentiated tolerability profile compared to peginterferon alfa (alfa). In Phase 2b clinical studies, Lambda administered in combination with ribavirin (RBV) was efficacious in patients with hepatitis C virus (HCV) infe...

Journal: :Open forum infectious diseases 2016
Kimberly Page Ali Mirzazadeh Thomas M Rice Jason Grebely Arthur Y Kim Andrea L Cox Meghan D Morris Margaret Hellard Julie Bruneau Naglaa H Shoukry Gregory J Dore Lisa Maher Andrew R Lloyd Georg Lauer Maria Prins Barbara H McGovern

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clear...

Journal: :Journal of Interferon & Cytokine Research 2014

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