Ovine interferon-gamma (IFN-γ) cDNA was isolated from total mRNA of peripheral blood mononuclear cells from indigenous sheep by reverse transcription PCR. The cDNA was successfully cloned, sequenced and expressed in Escherichia coli as thioredoxin fusion protein. Sequence comparison of Indian sheep IFN-γ showed high nucleotide homology with published IFN-γ sequences of sheep and other species o...

OBJECTIVES Compare the effect of different doses of red maca on gamma interferon (IFN-γ) levels in ovariectomized rats (OVX). MATERIALS AND METHODS Adult female rats were randomly divided into the following six groups: Group 1: pseudo-ovariectomized rats (PO); Group 2: OVX rats; Group 3: OVX rats treated with 4 ug/kg estradiol; and Group 4, 5 and 6: OVX rats treated with red maca extracts wit...

Mice were inoculated intraperitoneally wih 34 different types of vegetable juices, and interferon-gamma (IFN-γ) and interleukin-4 (IL-4) were measured as markers for the induction of Th1 and Th2 cells, respectively. Serum IFN-γ level was markedly increased in mice inoculated with bitter gourd (Momordica charantia) juice, but IL-4 levels were not increased with any of the 34 vegetable juices. Te...

Objective: The purpose of this study was to investigate the effect of moderate and high intensity endurance trainings with genistein consumption on tumor necrosis factor alpha (TNF- α) and interferon gamma (INF- γ) in streptozotocin induced diabetic rats. Materials and Methods: In this experimental study, 64 male diabetic rats were randomly assigned into 8 groups of 8 (1) first week control (2...

Objective: Paraquat (PQ) is a herbicide which induces oxidative stress and inflammation. Anti-inflammatory and anti-oxidant effects were shown for Zataria multiflora (Z. multiflora) and carvacrol previously. The effects of Z. multiflora hydroalcoholic extract and carvacrol on systemic inflammation and oxidative stressinduced by inhaled PQ were examine...

Interferon-gamma (IFN-γ) is a pleiotropic cytokine that exerts anti-tumor and anti-osteoclastogenic effects. Although transcriptional and post-transcriptional regulation of IFN-γ is well understood, subsequent modifications of secreted IFN-γ are not fully elucidated. Previous research indicates that some cancer cells escape immune surveillance and metastasize into bone tissue by inducing osteoc...

Noninvasive serum markers for assessment of liver fibrosis in chronic hepatitis B (CHB) patients have not been well-studied. The present study was to evaluate the predictive value of serum interferon gamma-inducible protein-10 (IP-10/CXCL10) and the interferon (IFN)-γ/interleukin (IL)-4 ratio for liver fibrosis progression in CHB patients. A total of 180 CHB patients were categorized into four ...

BACKGROUND Based on differences in individual immune responses to the hepatitis B virus (HBV), between 5% and 10% of patients become persistently infected with the virus, which leads to the determination of chronic HBV. Cytokines such as interferon gamma (IFN-γ) are secretory proteins that play important roles in both innate and adaptive immune responses. Functional studies have demonstrated th...