with up to 400 million affected people worldwide, chronic hepatitis b virus (hbv) infection is still a major health care problem. during the last decade, several novel therapeutic approaches have been developed and evaluated. in most regions of the world, interferon-α (ifn-α), and nucleos(t)ide analogues are currently approved. despite major improvements, none of the existing therapies is optim...

background: available evidence shows that tetracycline family has cellular and molecular mechanisms to protect neurons and oligodendrocytes by modulating matrix metalloproteinases. we tried to compare the effectiveness of intramuscular and subcutaneous interferon beta-1a (inf-β1a) in combination with oral doxycycline among patient with relapsing remitting multiple sclerosis (rrms) and secondary...

background: cytokines and specially interferon-gamma (ifn-g) are largely responsible for the regulation of the protective im­mune response against mycobacterial infections. several studies have clarified the importance of common variants of ifn- g gene regarding the susceptibility to tuberculosis. bacille calmette-guérin (bcg) vaccine that is used to prevent se­vere forms of tuberculosis could ...

Orthodontic treatment with fixed appliances that is mediated by the power forces of apparatus might lead to changes in blood circulation, predispose a number complications such as tooth movement and contributes morphological bone tissue remodeling. We have investigated 126 patients aged 16–35 years after appliance bracket therapy has caused orthodontically induced gingival hyperplasia. Immunolo...

tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. we evaluated the efficacy of interferon-gamma (ifn-gamma) and adenosine deaminase (ada) for diagnosing tuberculosis pericarditis in a cohort of iranian patients presenting with pericarditis. we enrolled 38 patients with presentation of pericarditis. all patients underwent di...

Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum women reproductive age with pulmonary tuberculosis (TB). Materials methods. We studied γ-interferon, α, cortisol, testosterone 18-45 years old newly diagnosed TB (n = 47) compared same indices without no previous 35)...

background: pegylated interferon and ribavirin are currently one of the accepted treatment for chronic hepatitis c. dermatologic complications of interferon have been reported, but to date a few cases of bacterial cellulitis; a rare and severe complication, have been published. cellulitis is a common infectious process affecting the skin and subcutaneous tissues which results in significant mor...

conclusions it can be concluded that the rsm is an effective method for the optimization of recombinant protein expression using synthetic genes in e. coli. results the proposed optimum fermentation condition consisted of 7.81 g l-1 glucose, od 600 nm prior induction 1.66 and induction temperature of 30.27°c. the model prediction of 0.267 g l-1 of rhifn-β and 0.961 g l-1 of acetate at the optim...

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Interferon-beta is one of the most widely prescribed disease-modifying therapies for multiple sclerosis patients. However, this treatment only partially effective, and a significant proportion patients do not respond to drug. This paper proposes an alternative fuzzy logic system, based on opinion neurology expert, classify relapsing–remitting as high, medium, or low responders interferon-beta. ...