We have demonstrated a chip-based diagnostics tool for the quantification of metabolites, using specific enzymes, to study enzyme kinetics and calculate the Michaelis-Menten constant. An array of 256×256 ion-sensitive field effect transistors (ISFETs) fabricated in a complementary metal oxide semiconductor (CMOS) process is used for this prototype. We have used hexokinase enzyme reaction on the...

The integrated modeling of land use and transportation choices involves analyzing a continuum of choices that characterize people’s lifestyles across temporal scales. This includes long-term choices such as residential and work location choices that affect land-use, medium-term choices such as vehicle ownership, and short-term choices such as travel mode choice that affect travel demand. Prior ...

Despite a high level of stochasticity and heterogeneity, a population of biological cells can collectively construct a complex structure that emerges from individual cell behaviors. Endothelial Cells (ECs), for example, create a vascular network with a tubular structure through interactions with the surrounding scaffold and other cells. Individual cells make a series of discrete decisions wheth...

Despite recent advances in DNA chip technology current microarray gene expression studies are still affected by high noise levels, small sample sizes and large numbers of uninformative genes. Combining microarray data with cellular pathway data by using new integrative analysis methods could help to alleviate some of these problems and provide new biological insights. We present a method for le...