Asymmetric cell divisions (ACDs) result in two unequal daughter cells and are a hallmark of stem cells. ACDs can be achieved either by asymmetric partitioning of proteins and organelles or by asymmetric cell fate acquisition due to the microenvironment in which the daughters are placed. Increasing evidence suggests that in the mammalian epidermis, both of these processes occur. During embryonic...

Infections caused by pathogens colonization at wound sites in the process of bone healing are considered as one of the major reasons for the failure of guided bone regeneration (GBR). The objective of this study was to prepare a novel asymmetric collagen/chitosan GBR membrane containing minocycline-loaded chitosan nanoparticles. The morphologies of the membranes and nanoparticles were observed ...

An oral monolithic osmotically controlled delivery system for Nifedepine using asymmetric membrane technology was developed and evaluated. Unlike conventional osmotic systems, which require laser drilling, this system releases the drug in a controlled manner from asymmetric membrane coated core tablets. Asymmetric membrane is formed by dry process with phase inversion technology process using c...

Mixed-conducting dense ceramic membranes have attracted considerable attention because of their potential application in oxygen separation, oxyfuel combustion and catalytic membrane reaction processes. However, the development of robust mixed-conducting membranes with both high permeability and stability is still a major challenge. In this paper, a crack-free asymmetric tubular membrane made of...

Fixation of purified sarcoplasmic reticulum (SR) membrane vesicles, using glutaraldehyde supplemented with 1% tannic acid, reveals newly visualized ultrastructure in thin sections. The trilaminar appearance of the membrane is highly asymmetric; the outer electron-opaque layer is appreciably wider (70 A) than the inner layer (20 A). The asymmetry is not referable to lack of penetration of the ta...

The total volume of water on Earth is circa 300 million cubic miles, with close to 98.0% being salt water and the remaining 2.0% fresh water. It has been increasingly more challenging to harvest fresh water from surface water, seawater and even from wastewater due to the combination of factors, viz. burgeoning population growth, rapid industrialization and climate change. Recently, membrane dis...

A biomimetic aluminum oxide membrane having asymmetric channels with a minimum diameter of 20 nm, maximum 80 and length 5 µm was prepared using square pulse anodization. The effectively permitted transfer anions only showed an ionic current rectification characteristic ratio 2.4. After the sulfonic acid group introduced by surface modification, cations 2.7. This modulation direction consistent ...

A central feature of most stem cells is the ability to self-renew and undergo differentiation via asymmetric division. However, during asymmetric division the role of phosphatidylinositol (PI) lipids and their regulators is not well established. Here, we show that the sole type I PI transfer protein, Vibrator, controls asymmetric division of Drosophilaneural stem cells (NSCs) by physically anch...