The mechanism of Ca2+ sensitization of contraction has not been elucidated in airway smooth muscle (SM). To determine the role of a small G protein, rhoA p21, and its target protein, rho-associated coiled coil-forming protein kinase (ROCK), in receptor-coupled Ca2+ sensitization of airway SM, we studied the effect of (+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclohexane carboxamide dihydrochl...

CASE A 64-year-old woman presented to the emergency department after falling when she tripped on a rock while doing yard work. Physical examination revealed an open deformity of the left forearm (Figure 1). Radial pulse was palpable, sensation was intact, and she had normal range of motion of the fingers. While awaiting radiographs, bedside ultrasound was performed (Video). Ultrasound revealed ...

Internal anal sphincter (IAS) tone plays an important role in rectoanal incontinence (RI). IAS tone may be compromised during aging, leading to RI in certain patients. We examined the influence of oxidative stress in the aging-associated decrease in IAS tone (AADI). Using adult (4-6 mo old) and aging (24-30 mo old) rats, we determined the effect of oxidative stress on IAS tone and the regulator...

The concrete–rock interfacial transition zone (ITZ) is generally considered the weak layer in hydraulic engineering, for it more permeable than intact concrete or rocks. water permeability of ITZ a critical parameter concerned with structural safety and durability. However, pore structure has not been investigated previously, mathematical model established. This study performed multi-scale expe...

an important concern in rock mechanics is non-homogeneity as joints or fault. this noticeable feature of failures in rock is appearance of slip surfaces or shear bands, the characteristics of that are associated with deformation being concentrated in a narrow zones and the surrounding material remaining intact. adopting the joints as fractures, fractures are well known for their effects on the ...

28 We previously reported that acute inhibition of the RhoA/Rho kinase (ROCK) pathway 29 normalized contractile function of diabetic rat hearts, but the underlying mechanism is unclear. 30 PKCβ2 has been proposed to play a major role in diabetic cardiomyopathy at least in part by 31 increasing oxidative stress. Further evidence suggests that PKC positively regulates RhoA 32 expression through i...

Knowledge about the permeability of surrounding rock (salt rock and mudstone interlayer) is an important topic, which acts as a key parameter to characterize the tightness of gas storage. The goal of experiments that test the permeability of gas storage facilities in rock salt is to develop a synthetic analogue to use as a permeability model. To address the permeability of a mudstone/salt layer...

We previously reported that acute inhibition of the RhoA/Rho kinase (ROCK) pathway normalized contractile function of diabetic rat hearts, but the underlying mechanism is unclear. Protein kinase C (PKC) β(2) has been proposed to play a major role in diabetic cardiomyopathy at least in part by increasing oxidative stress. Further evidence suggests that PKC positively regulates RhoA expression th...

Three cationic tracers, Sr2+, Co2+ and Cs+ were tested with a modified electromigration device by applying 2V, 3V 4V voltage gradients over an intact Grimsel granodiorite rock sample. An ideal plug-flow model advection-dispersion applied to analyze the breakthrough curves. Matrix characterization C-14-PMMA autoradiography scanning electron microscopy showed that in centimeter scale of rock, int...

Clay rock in the Tamusu (TMS) area Inner Mongolia province is one candidate as a geological disposal site for highly radioactive waste China. The diffusion behavior of HTO and Se(IV) clay was studied by through-diffusion (TD) experiments numerical analysis to determine spatial temporal variation. A minimum error conducted coefficients compacted TMS clay. TD experimental results showed that Se r...