نتایج جستجو برای: insulitis

تعداد نتایج: 749  

Journal: :The Journal of Experimental Medicine 1988
L S Wicker B J Miller A Chai M Terada Y Mullen

The development of autoimmune diabetes in the nonobese diabetic (NOD) mouse is controlled by at least three recessive loci, including one linked to the MHC. To determine whether any of these genetic loci exert their effects via the immune system, radiation bone marrow chimeras were constructed in which (NOD X B10)F1-irradiated recipients were reconstituted with NOD bone marrow cells. Unmanipula...

Journal: :Diabetes 2004
Luis Vence Christophe Benoist Diane Mathis

Type 1 diabetes is an autoimmune disease wherein autoreactive T-cells promote the specific destruction of pancreatic islet beta-cells. Evidence for a crucial role for Fas/FasL interactions in this destruction has been highly controversial because of the pleiotropic effects of Fas deficiency on the lymphoid and other systems. Fas-deficient mice are protected from spontaneous development of diabe...

2015
Antonia Diaz-Ganete Gloria Baena-Nieto Isabel M. Lomas-Romero Jose Francisco Lopez-Acosta Irene Cozar-Castellano Francisco Medina Carmen Segundo Alfonso M. Lechuga-Sancho

Ghrelin is a peptidic hormone, which stimulates cell proliferation and inhibits apoptosis in several tissues, including pancreas. In preclinical stage of type 1 diabetes, proinflammatory cytokines generate a destructive environment for β-cells known as insulitis, which results in loss of β-cell mass and impaired insulin secretion, leading to diabetes. Our aim was to demonstrate that ghrelin cou...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Angela M Magnuson Greg M Thurber Rainer H Kohler Ralph Weissleder Diane Mathis Christophe Benoist

Type-1 diabetes in the nonobese diabetic (NOD) mouse starts with an insulitis stage, wherein a mixed population of leukocytes invades the pancreas, followed by overt diabetes once enough insulin-producing β-cells are destroyed by invading immunocytes. Little is known of the dynamics of lymphocyte movement into the pancreas during disease progression. We used the Kaede transgenic mouse, whose ph...

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